{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T20:41:20Z","timestamp":1762980080250,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pregnancy"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>The objective of the present study was to evaluate the influence of second-trimester ultrasound markers on the incidence of Down syndrome among pregnant women of advanced maternal age. This was a retrospective cohort study on 889 singleton pregnancies between the 14th and 30th weeks, with maternal age \u2265 35 years, which would undergo genetic amniocentesis. The second-trimester ultrasound assessed the following markers: increased nuchal fold thickness, cardiac hyperechogenic focus, mild ventriculomegaly, choroid plexus cysts, uni- or bilateral renal pyelectasis, intestinal hyperechogenicity, single umbilical artery, short femur and humerus length, hand\/foot alterations, structural fetal malformation, and congenital heart disease. To investigate differences between the groups with and without markers, nonparametric tests consisting of the chi-square test or Fisher\u2019s exact test were used. Moreover, odds ratios with their respective 95% confidence intervals were calculated. Out of the 889 pregnant women, 131 (17.3%) presented markers and 758 (82.7%) did not present markers on the second-trimester ultrasound. Increased nuchal fold (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi mathvariant=\"normal\">P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) and structural malformation (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi mathvariant=\"normal\">P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) were the markers most associated with Down syndrome. The presence of one marker increased the relative risk 10.5-fold, while the presence of two or more markers increased the risk 13.5-fold. The presence of markers on the second-trimester ultrasound, especially thickened nuchal fold and structural malformation, increased the risk of Down syndrome among pregnant women with advanced maternal age.<\/jats:p>","DOI":"10.1155\/2014\/785730","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T17:02:33Z","timestamp":1395766953000},"page":"1-6","source":"Crossref","is-referenced-by-count":8,"title":["Influence of Second-Trimester Ultrasound Markers for Down Syndrome in Pregnant Women of Advanced Maternal Age"],"prefix":"10.1155","volume":"2014","author":[{"given":"Mariza","family":"Rumi Kataguiri","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Paulista School of Medicine\u2014Federal University of S\u00e3o Paulo (EPM-UNIFESP), Rua Carlos Weber, 956, apto. 113 Visage, Vila Leopoldina, 05303-000 S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-2532","authenticated-orcid":true,"given":"Edward","family":"Araujo J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Paulista School of Medicine\u2014Federal University of S\u00e3o Paulo (EPM-UNIFESP), Rua Carlos Weber, 956, apto. 113 Visage, Vila Leopoldina, 05303-000 S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Claudio","family":"Silva Bussamra","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Paulista School of Medicine\u2014Federal University of S\u00e3o Paulo (EPM-UNIFESP), Rua Carlos Weber, 956, apto. 113 Visage, Vila Leopoldina, 05303-000 S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano Marcondes","family":"Machado Nardozza","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Paulista School of 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