{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:02:40Z","timestamp":1740164560208,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Neurological Medicine"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Importance.<\/jats:italic>Medication-induced eosinophilia is an acknowledged, often self-limiting occurrence. Glatiramer acetate, a biologic injection used in the management of relapsing-remitting multiple sclerosis, is widely regarded as a safe and effective medication and lists eosinophilia as an infrequent side effect in its package insert. Contrary to reports of transient, benign drug-induced eosinophilia, we describe a case of probable glatiramer acetate-induced eosinophilia that ultimately culminated in respiratory distress, shock, and eosinophilic myocarditis.<jats:italic>Observations.<\/jats:italic>A 59-year-old female was admitted to the hospital after routine outpatient labs revealed leukocytosis (43,000 cells\/mm<jats:sup>3<\/jats:sup>) with pronounced hypereosinophilia (63%). This patient had been using glatiramer acetate without complication for over 10 years prior to admission. Leukocytosis and hypereosinophilia persisted as a myriad of diagnostic evaluations returned negative, ultimately leading to respiratory depression, shock, and myocarditis. Glatiramer acetate was held for the first time on day 6 of the hospital stay with subsequent resolution of leukocytosis, hypereosinophilia, respiratory distress, and shock.<jats:italic>Conclusions and Relevance.<\/jats:italic>Glatiramer acetate was probably the cause of this observed hypereosinophilia and the resulting complications. Reports of glatiramer-induced eosinophilia are rare, and few case reports regarding medication-induced hypereosinophilia describe the severe systemic manifestations seen in this patient.<\/jats:p>","DOI":"10.1155\/2014\/786342","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T17:09:15Z","timestamp":1404407355000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["Diagnosis of Exclusion: A Case Report of Probable Glatiramer Acetate-Induced Eosinophilic Myocarditis"],"prefix":"10.1155","volume":"2014","author":[{"given":"Christopher J.","family":"Michaud","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Spectrum Health, 100 Michigan Street NE, MC 001, Grand Rapids, MI 49503, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather M.","family":"Bockheim","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Spectrum Health, 100 Michigan Street NE, MC 001, Grand Rapids, MI 49503, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3225-3099","authenticated-orcid":true,"given":"Muhammad","family":"Nabeel","sequence":"additional","affiliation":[{"name":"Internal Medicine, Spectrum Health, Grand Rapids, MI 49503, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy E.","family":"Daum","sequence":"additional","affiliation":[{"name":"Pulmonary Critical Care, Spectrum Health Medical Group, Grand Rapids, MI 49503, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.41"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2165\/11206430-000000000-00000"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907839"},{"key":"4"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23938"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1177\/0192623311424169"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21079"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.64"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198708133170703"},{"issue":"2","key":"10","first-page":"81","volume":"105","year":"2005","journal-title":"Acta Neurologica Belgica"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.3.701"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004678.pub2"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.01.017"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000257109.61671.06"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03967.x"},{"issue":"3","key":"17","first-page":"357","volume":"137","year":"2001","journal-title":"Archives of Dermatology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"}],"container-title":["Case Reports in Neurological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crinm\/2014\/786342.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crinm\/2014\/786342.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crinm\/2014\/786342.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T04:48:04Z","timestamp":1469767684000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crinm\/2014\/786342\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":17,"alternative-id":["786342","786342"],"URL":"https:\/\/doi.org\/10.1155\/2014\/786342","relation":{},"ISSN":["2090-6668","2090-6676"],"issn-type":[{"type":"print","value":"2090-6668"},{"type":"electronic","value":"2090-6676"}],"subject":[],"published":{"date-parts":[[2014]]}}}