{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:18:21Z","timestamp":1760955501454,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Renal failure is a common complication among critically ill patients. Timing, dosage, and mode of renal replacement (RRT) are under debate, but also anticoagulation strategies and vascular access interfere with dialysis success. We present a retrospective, five-year evaluation of patients requiring RRT on a multidisciplinary 50-bed surgical intensive care unit of a university hospital with special regard to anticoagulation strategies and vascular access. Anticoagulation was preferably performed with unfractionated heparin or regional citrate application (RAC). Bleeding and suspected HIT-II were most common causes for RAC. In CVVHD mode filter life span was significantly longer under RAC compared to heparin or other anticoagulation strategies (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). Femoral vascular access was associated with reduced filter life span (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.012<\/mml:mn><\/mml:math>), especially under heparin anticoagulation (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.015<\/mml:mn><\/mml:math>). Patients on RAC had higher rates of metabolic alkalosis (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), required more transfusions (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.045<\/mml:mn><\/mml:math>), and showed higher illness severity measured by SOFA scores (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). RRT with unfractionated heparin represented the most common anticoagulation strategy in this study population. However, patients with bleeding risk and severe organ dysfunction were more likely placed on RAC. Citrate provided longer filter life spans regardless of vascular access site. Attention has to be paid to metabolic disturbances.<\/jats:p>","DOI":"10.1155\/2014\/808320","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T21:02:33Z","timestamp":1418158953000},"page":"1-7","source":"Crossref","is-referenced-by-count":6,"title":["Anticoagulation Strategies in Venovenous Hemodialysis in Critically Ill Patients: A Five-Year Evaluation in a Surgical Intensive Care Unit"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1746-7024","authenticated-orcid":true,"given":"Christoph","family":"Sponholz","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4954-1820","authenticated-orcid":true,"given":"Ole","family":"Bayer","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Kabisch","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Wurm","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Ebert","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany"},{"name":"Center for Sepsis Control and Care (CSCC), Integrated Research and Treatment Center, Jena University Hospital, 07747 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6499-4900","authenticated-orcid":true,"given":"Andreas","family":"Kortgen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany"},{"name":"Center for Sepsis Control and Care (CSCC), Integrated Research and Treatment Center, Jena University Hospital, 07747 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.7.813"},{"issue":"7","key":"2","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s001340051281","volume":"26","year":"2000","journal-title":"Intensive Care Medicine"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0b013e32834cd360"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2011.88"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1186\/cc9358"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2011.06.016"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.11.030"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-011-2438-3"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0754-4"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2012.01101.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1186\/cc11403"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr510"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1159\/0000102112"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2008.00553.x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181d454b3"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06570711"},{"issue":"1","key":"17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1681\/ASN.V71145","volume":"7","year":"1996","journal-title":"Journal of the American Society of Nephrology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-0044-y"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq575"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-2047-x"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00342.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181953c5e"},{"issue":"5","key":"23","first-page":"602","volume":"20","year":"2007","journal-title":"Journal of Nephrology"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12157"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2012.678834"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1092872"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1186\/cc5937"},{"key":"28","first-page":"178","volume":"156","year":"2007","journal-title":"Contributions to Nephrology"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1159\/000079171"}],"container-title":["The Scientific World Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2014\/808320.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2014\/808320.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2014\/808320.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T03:50:52Z","timestamp":1650772252000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/tswj\/2014\/808320\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":29,"alternative-id":["808320","808320"],"URL":"https:\/\/doi.org\/10.1155\/2014\/808320","relation":{},"ISSN":["2356-6140","1537-744X"],"issn-type":[{"type":"print","value":"2356-6140"},{"type":"electronic","value":"1537-744X"}],"subject":[],"published":{"date-parts":[[2014]]}}}