{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T15:24:30Z","timestamp":1771514670851,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T00:00:00Z","timestamp":1414540800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Scholarly Research Notices"],"published-print":{"date-parts":[[2014,10,29]]},"abstract":"<jats:p>Lornoxicam is a selective cyclooxygenase-1 and cyclooxygenase-2 inhibitor that exhibits anti-inflammatory, analgesic, and antipyretic activities. It is used in osteoarthritis and rheumatoid arthritis; and in treatment of postoperative pain and primary dysmenorrhoea. Lornoxicam is completely insoluble in water but soluble in alkaline solutions. Hydrotropic solubilization is a technique used to increase the aqueous solubility of poorly water-soluble drugs and the present study was aimed at developing a hydrotropic technique to increase the solubility of lornoxicam, using 2\u2009M sodium benzoate as the hydrotropic agent. Beer\u2019s law was obeyed in the concentration range of 4\u201324\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL at 381\u2009nm. The solubility of lornoxicam in distilled water considerably increased with the addition of a hydrotropic agent. The analysis of tablets indicated good correlation between the amounts estimated and label claim. The LOD and LOQ of lornoxicam were found to be 0.34\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL and 1.038\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL, respectively, indicating good sensitivity of the proposed method. The percentage recovery was found to be 99.99%\u2013100.21%. Thus the proposed method is new, simple, environmentally friendly, accurate, and cost effective and can be successfully employed in routine analysis of lornoxicam in tablets.<\/jats:p>","DOI":"10.1155\/2014\/810128","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T21:03:38Z","timestamp":1414616618000},"page":"1-4","source":"Crossref","is-referenced-by-count":5,"title":["Application of Hydrotropic Solubilization in Spectrophotometric Estimation of Lornoxicam from Tablets"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8172-9626","authenticated-orcid":true,"given":"Sindhu","family":"Abraham","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, M.S. Ramaiah College of Pharmacy, MSRIT Post, MSR Nagar, Bangalore 560054, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajamanickam","family":"Deveswaran","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, M.S. Ramaiah College of Pharmacy, MSRIT Post, MSR Nagar, Bangalore 560054, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Furtado","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, M.S. Ramaiah College of Pharmacy, MSRIT Post, MSR Nagar, Bangalore 560054, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinivasan","family":"Bharath","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, M.S. Ramaiah College of Pharmacy, MSRIT Post, MSR Nagar, Bangalore 560054, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varadharajan","family":"Madhavan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, M.S. Ramaiah College of Pharmacy, MSRIT Post, MSR Nagar, Bangalore 560054, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"1","key":"1","first-page":"51","volume":"1","year":"2010","journal-title":"International Journal of Pharma Sciences and Research"},{"issue":"3","key":"2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.33786\/JCPR.2011.v01i03.001","volume":"1","year":"2011","journal-title":"Journal of Current Pharmaceutical Research"},{"issue":"1","key":"3","first-page":"57","volume":"5","year":"2012","journal-title":"Asian Journal of Research Chemistry"},{"issue":"5","key":"4","first-page":"573","volume":"2","year":"2012","journal-title":"American Journal of Pharm Tech Research"},{"issue":"1","key":"5","first-page":"232","volume":"4","year":"2012","journal-title":"International Journal of ChemTech Research"},{"issue":"1","key":"6","doi-asserted-by":"crossref","first-page":"385","DOI":"10.33786\/JCPR.2011.v02i01.003","volume":"2","year":"2011","journal-title":"Journal of Current Pharmaceutical Research"},{"issue":"3","key":"7","doi-asserted-by":"crossref","first-page":"184","DOI":"10.4103\/2229-4708.90359","volume":"2","year":"2011","journal-title":"Pharmaceutical Methods"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474X.99021"},{"issue":"4","key":"9","first-page":"298","volume":"2","year":"2013","journal-title":"Scholar's Academic Journal of Pharmacy"},{"issue":"3","key":"10","first-page":"17","volume":"8","year":"2012","journal-title":"Iraqi Journal of Applied Physics"}],"container-title":["International Scholarly Research Notices"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/810128.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/810128.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/810128.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T20:32:04Z","timestamp":1607545924000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/isrn\/2014\/810128\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,29]]},"references-count":10,"alternative-id":["810128","810128"],"URL":"https:\/\/doi.org\/10.1155\/2014\/810128","relation":{},"ISSN":["2356-7872"],"issn-type":[{"value":"2356-7872","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,29]]}}}