{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:50Z","timestamp":1787017730522,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA109525"],"award-info":[{"award-number":["R01 CA109525"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Florence and Herbert Irving Clinical Research Career Award","award":["R01 CA109525"],"award-info":[{"award-number":["R01 CA109525"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>\n                    Salivary duct carcinoma (SDC) is an aggressive malignant tumor with a high mortality, which resembles high-grade breast ductal carcinoma in morphology. The parotid gland is the most common location. Its molecular genetic characteristics remain largely unknown. We have previously reported high incidence of\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    somatic mutations in head and neck squamous cell carcinoma, particularly in pharyngeal cancers. Here we examined the\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    gene expression status and hotspot mutations in six cases of SDC by immunohistochemistry and genomic DNA sequencing. Immunohistochemistry showed that\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    expression was elevated in all six patients with SDC. By DNA sequencing, two hotspot mutations of the\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    gene, E545K (exon 9) and H1047R (exon 20), were identified in two of the six cases. Our results support that oncogenic\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    is upregulated and frequently mutated in human SDC, adding evidence that\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    oncogenic pathway is critical in the tumorigenesis of SDC, and may be a plausible drug target for this rare disease.\n                  <\/jats:p>","DOI":"10.1155\/2014\/810487","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T16:23:11Z","timestamp":1389198191000},"page":"1-7","source":"Crossref","is-referenced-by-count":12,"title":["Oncogenic\n                    <i>PIK3CA<\/i>\n                    Mutation and Dysregulation in Human Salivary Duct Carcinoma"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2878-1251","authenticated-orcid":true,"given":"Wanglong","family":"Qiu","sequence":"first","affiliation":[{"name":"The Department of Pathology, Columbia University Medical Center, 1130 Saint Nicholas Avenue, ICRC 10-04, New York, NY 10032, USA"},{"name":"Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 Saint Nicholas Avenue, ICRC 10-04, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Xia","family":"Tong","sequence":"additional","affiliation":[{"name":"The Department of Pathology, Columbia University Medical Center, 1130 Saint Nicholas Avenue, ICRC 10-04, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Turk","sequence":"additional","affiliation":[{"name":"The Department of Pathology, Columbia University Medical Center, 1130 Saint Nicholas Avenue, ICRC 10-04, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanny G.","family":"Close","sequence":"additional","affiliation":[{"name":"The Department of Otolaryngology and Head and Neck Surgery, Columbia University Medical Center, 1130 Saint Nicholas Avenue, ICRC 10-04, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore M.","family":"Caruana","sequence":"additional","affiliation":[{"name":"The Department of Otolaryngology and Head and Neck Surgery, Columbia University Medical Center, 1130 Saint Nicholas Avenue, ICRC 10-04, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria H.","family":"Su","sequence":"additional","affiliation":[{"name":"The Department of Pathology, Columbia University Medical Center, 1130 Saint Nicholas Avenue, ICRC 10-04, New York, NY 10032, USA"},{"name":"Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 Saint Nicholas Avenue, ICRC 10-04, New York, NY 10032, USA"},{"name":"The Department of Otolaryngology and Head and Neck Surgery, Columbia University Medical Center, 1130 Saint Nicholas Avenue, ICRC 10-04, New York, NY 10032, 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