{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T13:37:20Z","timestamp":1770385040904,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>A documented case of canine granulocytic anaplasmosis coupled with the molecular characterization of the etiological agent is reported for the first time in Northern Italy. The patient showed nonspecific clinical signs such as fever and weight loss. The most relevant clinicopathological findings were thrombocytopenia, hypoalbuminemia, and normal azotemic proteinuria consistent with glomerular diseases. Blood smear examination revealed the presence of intracytoplasmatic inclusions in neutrophils associated with high positive serology for<jats:italic>Anaplasma phagocytophilum<\/jats:italic>. PCR analysis and sequencing of the amplicon confirm serological diagnosis of<jats:italic>A. phagocytophilum<\/jats:italic>. Phylogenetic analysis evidenced that the detected bacterial strain belongs to the<jats:italic>A. phagocytophilum<\/jats:italic>Europe 1 lineage. Data indicates that<jats:italic>A. phagocytophilum<\/jats:italic>circulates in natural environments of Emilia-Romagna region (Northern Italy) and its prevalence in dogs could be underestimated because the clinical signs are frequently nonspecific and a certain diagnosis requires the combination of clinicopathological and molecular assays. Pets living in this area should be regularly monitored and treated for ectoparasites to minimize health risks for humans and pets. Also, surveillance of<jats:italic>A. phagocytophilum<\/jats:italic>should be improved in Northern Italy and canine anaplasmosis should be considered in differential diagnosis of persistent proteinuria.<\/jats:p>","DOI":"10.1155\/2014\/810587","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T17:12:09Z","timestamp":1401988329000},"page":"1-6","source":"Crossref","is-referenced-by-count":14,"title":["Clinicopathological and Molecular Findings in a Case of Canine<i>Anaplasma phagocytophilum<\/i>Infection in Northern Italy"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8259-6458","authenticated-orcid":true,"given":"Francesco","family":"Dondi","sequence":"first","affiliation":[{"name":"Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell\u2019Emilia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9680-3435","authenticated-orcid":true,"given":"Samanta","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell\u2019Emilia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9004-3834","authenticated-orcid":true,"given":"Chiara","family":"Agnoli","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell\u2019Emilia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Mengoli","sequence":"additional","affiliation":[{"name":"\u201cDr Nicola Mengoli\u201d Veterinary Clinic, Via Di Mezzo 51, 40060 Toscanella di Dozza, 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