{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T19:18:51Z","timestamp":1781551131735,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>AP-1 and NF-<jats:italic>\u03ba<\/jats:italic>B inhibitors, namely, DTCM-G and DHMEQ, were investigated in male Wistar rats with severe colitis, induced by TNBS. The animals were randomized into 3 groups. The control group received 0.5\u2009mL of 0.5% of the vehicle i.p., the DTCM-G group received 22.5\u2009mg\/kg body weight DTCM-G in 0.5% i.p., and the DHMEQ group received 15\u2009mg\/kg body weight DHMEQ i.p., all twice daily for 5 days. The body weight losses and mortality rates were significantly higher in the control group than those in DTCM-G-treated and DHMEQ-treated groups. The endoscopic inflammation scores in the control, DTCM-G-treated, and DHMEQ-treated groups were 6.3 \u00b1 0.7, 1.0 \u00b1 0.3, and 0.7 \u00b1 0.3, respectively (<jats:italic>P<\/jats:italic>= 0.004 and 0.02, resp.). The inflammation scores as assessed by the macroscopic appearance were 4.3 \u00b1 0.8, 0.7 \u00b1 0.3, and 1.2 \u00b1 0.4 in the control, DTCM-G-treated, and DHMEQ-treated groups, respectively (<jats:italic>P<\/jats:italic>= 0.01 and 0.009, resp.). The histopathological inflammation scores were 6.4 \u00b1 0.7, 2.0 \u00b1 1.0, and 2.2 \u00b1 0.6 in the control, DTCM-G-treated, and DHMEQ-treated groups, respectively (<jats:italic>P<\/jats:italic>= 0.03 and 0.01, resp.). It was concluded that DTCM-G and DHMEQ exhibit strong anti-inflammatory and anticancer activities with no apparent toxicity, which make them excellent drug candidates for clinical use in inflammatory bowel diseases.<\/jats:p>","DOI":"10.1155\/2014\/813804","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T21:17:25Z","timestamp":1391116645000},"page":"1-8","source":"Crossref","is-referenced-by-count":16,"title":["Amelioration of Severe TNBS Induced Colitis by Novel AP-1 and NF-<i>\u03ba<\/i>B Inhibitors in Rats"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3398-3288","authenticated-orcid":true,"given":"Magdy","family":"El-Salhy","sequence":"first","affiliation":[{"name":"Section for Gastroenterology, Department of Medicine, Stord Helse-Fonna Hospital, P.O Box 4000, 54 09 Stord, Norway"},{"name":"Division of Gastroenterology, Department of Clinical Medicine, University of Bergen, P.O Box 7800, 5020 Bergen, 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