{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:15:19Z","timestamp":1791422119775,"version":"4.3.3"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,2,3]],"date-time":"2014-02-03T00:00:00Z","timestamp":1391385600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Surgery"],"published-print":{"date-parts":[[2014,2,3]]},"abstract":"<jats:p><jats:italic>Introduction.<\/jats:italic> Malignant pleural mesothelioma (MPM) is an aggressive cancer arising from pleural mesothelium. Surgery aims to either cure the disease or control the symptoms. Two surgical procedures exist: extrapleural pneumonectomy (EPP) and pleurectomy\/decortication (P\/D). In this systematic review we assess current evidence on safety and efficacy of surgery. <jats:italic>Methods.<\/jats:italic> Five electronic databases were reviewed from January 1990 to January 2013. Studies were selected according to a predefined protocol. Primary endpoint was overall survival. Secondary endpoints included quality of life, disease-free survival, disease recurrence, morbidity, and length of hospital stay. <jats:italic>Results.<\/jats:italic> Sixteen studies were included. Median survival ranged from 8.1 to 32 months for P\/D and from 6.9 to 46.9 months for EPP. Perioperative mortality was 0%\u20139.8% and 3.2%\u201312.5%, respectively. Perioperative morbidity was 5.9%\u201355% for P\/D and 10%\u201382.6% for EPP. Average length of stay was 7 days for P\/D and 9 days for EPP. <jats:italic>Conclusion.<\/jats:italic> Current evidence cannot definitively answer which procedure (EPP or P\/D) is more beneficial in terms of survival and operative risks. This systematic review suggests that surgery in the context of trimodality therapy offers acceptable perioperative outcomes and long-term survival. Centres specialising in MPM management have better results.<\/jats:p>","DOI":"10.1155\/2014\/817203","type":"journal-article","created":{"date-parts":[[2014,2,3]],"date-time":"2014-02-03T21:02:03Z","timestamp":1391461323000},"page":"1-13","source":"Crossref","is-referenced-by-count":18,"title":["Surgical Management of Malignant Pleural Mesothelioma: Impact of Surgery on Survival and Quality of Life\u2014Relation to Chemotherapy, Radiotherapy, and Alternative Therapies"],"prefix":"10.1155","volume":"2014","author":[{"given":"Sotiris","family":"Papaspyros","sequence":"first","affiliation":[{"name":"Cardiothoracic Directorate, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6923-3134","authenticated-orcid":true,"given":"Sayonara","family":"Papaspyros","sequence":"additional","affiliation":[{"name":"Biomedical Sciences, Leeds Metropolitan University, Portland Way, Leeds LS1 3HE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"27","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1056\/NEJMra050152","volume":"353","year":"2005","journal-title":"The New England Journal of Medicine"},{"key":"14","first-page":"55","volume-title":"The history of mesothelioma in Australia 1945\u20132001","year":"2002"},{"key":"32","year":"2004"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602307"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690105"},{"key":"29","first-page":"14","volume-title":"Surviving the asbestos epidemic","year":"2001"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17108-0"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S1547-4127(04)00108-2"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2010-0185"},{"issue":"1","key":"3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1136\/thx.31.1.15","volume":"31","year":"1976","journal-title":"Thorax"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(01)00594-2"},{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(02)00273-7"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70149-8"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2010.256271"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181ed0489"},{"issue":"4","key":"6","first-page":"428","volume":"1","year":"2012","journal-title":"Annals of Cardiothoracic Surgery"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.06.066"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.07.032"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.10.054"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2007.166322"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31824ab6c5"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2011.12.009"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2008.06.010"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(01)00995-2"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3182288af9"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(99)70469-1"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.3943"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.05.036"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.5604"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm093"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-22"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00039510"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.09.025"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2225-319X.2012.11.05"},{"issue":"4","key":"39","first-page":"502","volume":"1","year":"2012","journal-title":"Annals of Cardiothoracic Surgery"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.136"},{"issue":"4","key":"19","first-page":"508","volume":"1","year":"2012","journal-title":"Annals of Cardiothoracic Surgery"},{"issue":"4","key":"26","first-page":"457","volume":"1","year":"2012","journal-title":"Annals of Cardiothoracic Surgery"}],"container-title":["ISRN Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/817203.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/817203.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/817203.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T20:37:13Z","timestamp":1607546233000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/isrn\/2014\/817203\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,3]]},"references-count":38,"alternative-id":["817203","817203"],"URL":"https:\/\/doi.org\/10.1155\/2014\/817203","relation":{},"ISSN":["2090-5793"],"issn-type":[{"value":"2090-5793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,3]]}}}