{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:41:04Z","timestamp":1773283264729,"version":"3.50.1"},"reference-count":30,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Interdisciplinary Perspectives on Infectious Diseases"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>As a result of the ever increasing problem of multiresistant bacteria, we instituted a surveillance program with the aim of identifying the basic molecular properties of ESBL in our environment. About 197 isolates of<jats:italic>Escherichia coli<\/jats:italic>and<jats:italic>Klebsiella pneumoniae<\/jats:italic>were selected and tested for ESBL production and antimicrobial susceptibility. Plasmid profiles were determined and curing ability was tested. ESBL prevalence was 26.4% for all isolates tested, with<jats:italic>E. coli<\/jats:italic>having a greater proportion. There was absolute resistance to ampicilin, tetracycline, and co-trimaxole among tested isolates. There was above average susceptibility to the 2nd and 3rd generation cephalosporins. Plasmid profiles of tested isolates ranged from 9\u2009kbp to 26\u2009kbp with average of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn>14.99<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>2.3<\/mml:mn><\/mml:math>\u2009kbp for<jats:italic>E. coli<\/jats:italic>and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn>20.98<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>1.8<\/mml:mn><\/mml:math>\u2009kbp<jats:italic>K. pneumoniae<\/jats:italic>, 9.6% of ESBL positive<jats:italic>E. coli<\/jats:italic>plasmids were cured, while 3.9% of<jats:italic>K. pneumoniae<\/jats:italic>plasmids were cured after treatment. The present study shows an upsurge in ESBL acquisition by gram negative bacteria and evidence of cocirculation of varying subtypes of ESBL with both plasmid transmissible and chromosome encoded subtypes. This calls for universal surveillance and more effort towards molecular epidemiology of this public health treatment.<\/jats:p>","DOI":"10.1155\/2014\/819896","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T04:02:44Z","timestamp":1395720164000},"page":"1-7","source":"Crossref","is-referenced-by-count":16,"title":["A Multicenter Study of Beta-Lactamase Resistant<i>Escherichia coli<\/i>and<i>Klebsiella pneumoniae<\/i>Reveals High Level Chromosome Mediated Extended Spectrum<i>\u03b2<\/i>Lactamase Resistance in Ogun State, Nigeria"],"prefix":"10.1155","volume":"2014","author":[{"given":"Folasoge A.","family":"Adeyankinnu","sequence":"first","affiliation":[{"name":"Microbiology Unit, Pathology Department, Federal Medical Centre, Abeokuta, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babatunde O.","family":"Motayo","sequence":"additional","affiliation":[{"name":"Microbiology Unit, Pathology Department, Federal Medical Centre, Abeokuta, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinniyi","family":"Akinduti","sequence":"additional","affiliation":[{"name":"Department of Vet Microbiology and Parasitology, Federal University of Agriculture, Abeokuta, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Akinbo","sequence":"additional","affiliation":[{"name":"Microbiology Unit, Pathology Department, Federal Medical Centre, Abeokuta, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph I.","family":"Ogiogwa","sequence":"additional","affiliation":[{"name":"Microbiology Unit, Pathology Department, Federal Medical Centre, Abeokuta, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bukola W.","family":"Aboderin","sequence":"additional","affiliation":[{"name":"Microbiology Unit, Pathology Department, Federal Medical Centre, Abeokuta, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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