{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:14:16Z","timestamp":1785464056902,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Centro de Investigaci\u00f3n en Alimentaci\u00f3n y Desarrollo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Human Giardiosis is a public health problem in Mexico, where the national prevalence was estimated to be up to 68%. Misuse of antiprotozoal drugs may result in low effectiveness and undesirable side effects. Research on natural products is a good strategy for discovering more effective antiparasitic compounds. This study evaluated the antigiardial activity of extracts of<jats:italic>Yucca baccata<\/jats:italic>, which is native to northwestern Mexico. Forty-two gerbils (females) were weighed and orally inoculated with<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn>5<\/mml:mn><mml:mo>\u00d7<\/mml:mo><mml:msup><mml:mrow><mml:mn>10<\/mml:mn><\/mml:mrow><mml:mrow><mml:mn>6<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:math><jats:italic>Giardia<\/jats:italic>trophozoites. Two gerbils were selected at random to confirm infection. Forty living gerbils were randomly allocated into 5 treatment groups (8 per group). Gerbils were randomly assigned to be treated with 24.4\u2009mg\/mL, 12.2\u2009mg\/mL, and 6.1\u2009mg\/mL of extracts, metronidazole (2\u2009mg\/mL) or PBS, which were intragastrically administered once per day for 3 days. Nine gerbils died during the study course. On day 10 postinfection, gerbils were euthanized and trophozoites were quantified.<jats:italic>Yucca<\/jats:italic>extracts reduced, albeit not significantly, the trophozoite counts in the duodenum segment. Only the high-extract concentration significantly reduced the trophozoite counts in the proximal segment and it was similar to that of metronidazole. Extracts of<jats:italic>Y. baccata<\/jats:italic>may represent an effective and natural therapeutic alternative for human giardiosis.<\/jats:p>","DOI":"10.1155\/2014\/823492","type":"journal-article","created":{"date-parts":[[2014,8,31]],"date-time":"2014-08-31T17:04:04Z","timestamp":1409504644000},"page":"1-6","source":"Crossref","is-referenced-by-count":8,"title":["Marked Antigiardial Activity of<i>Yucca baccata<\/i>Extracts: A Potential Natural Alternative for Treating Protozoan Infections"],"prefix":"10.1155","volume":"2014","author":[{"given":"Luis","family":"Quihui-Cota","sequence":"first","affiliation":[{"name":"Departamento de Nutrici\u00f3n P\u00fablica y Salud, Coordinaci\u00f3n de Nutrici\u00f3n, Centro de Investigaci\u00f3n en Alimentaci\u00f3n y Desarrollo, A.C. Carretera a La Victoria Km 0.6, 83304 Hermosillo, SON, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio","family":"Le\u00f3n-Trujillo","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n P\u00fablica y Salud, Coordinaci\u00f3n de Nutrici\u00f3n, Centro de Investigaci\u00f3n en Alimentaci\u00f3n y Desarrollo, A.C. Carretera a La Victoria Km 0.6, 83304 Hermosillo, SON, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"Astiazar\u00e1n-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Metabolismo, Coordinaci\u00f3n de Nutrici\u00f3n, Centro de Investigaci\u00f3n en Alimentaci\u00f3n y Desarrollo, A.C. Carretera a La Victoria Km 0.6, 83304 Hermosillo, SON, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n","family":"Esparza-Romero","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n P\u00fablica y Salud, Coordinaci\u00f3n de Nutrici\u00f3n, Centro de Investigaci\u00f3n en Alimentaci\u00f3n y Desarrollo, A.C. Carretera a La Victoria Km 0.6, 83304 Hermosillo, SON, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Refugio","family":"Robles","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias de los Alimentos, Centro de Investigaci\u00f3n en Alimentaci\u00f3n y Desarrollo, A.C. Carretera a La Victoria Km 0.6, 83304 Hermosillo, SON, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n E.","family":"Robles-Zepeda","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Qu\u00edmico Biol\u00f3gicas, Universidad de Sonora, Bulevar Luis Encinas y Rosales s\/n, 83000 Hermosillo, SON, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Canett","sequence":"additional","affiliation":[{"name":"Departamento de Investigaci\u00f3n y Posgrado en Alimentos, Universidad de Sonora, Bulevar Luis Encinas y Rosales s\/n, 83000 Hermosillo, SON, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"S\u00e1nchez-Escalante","sequence":"additional","affiliation":[{"name":"Herbario USON, Departamento de Investigaciones Cient\u00edficas y Tecnol\u00f3gica, Universidad de Sonora, Ni\u00f1os H\u00e9roes entre Rosales y Jos\u00e9 Mar\u00eda Pino Su\u00e1rez, Edificio 1A (Museo), Colonia Centro, 83000 Hermosillo, SON, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(99)01624-5"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.1.114-128.2001"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2009.11.010"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2005.03.027"},{"issue":"2","key":"6","first-page":"43","volume":"5","year":"2013","journal-title":"The International Journal of Mathematics and Mathematical Sciences"},{"key":"7","year":"2002"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1208\/aapsj080228"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000682"},{"issue":"1-2","key":"10","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jep.2005.04.025","volume":"100","year":"2005","journal-title":"Journal of Ethnopharmacology"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/269793"},{"key":"13","year":"2013"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.2000.01054.x"},{"issue":"9","key":"15","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.2527\/1999.7792554x","volume":"77","year":"1999","journal-title":"Journal of Animal Science"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19970143"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(01)00394-6"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1006\/expr.2000.4514"},{"key":"20","year":"2011"},{"key":"22","year":"2009"},{"issue":"12","key":"24","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1128\/AAC.37.12.2668","volume":"37","year":"1993","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-011-9208-5"},{"key":"27","year":"1978"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182011002137"},{"issue":"5","key":"29","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1442-200x.2005.02110.x","volume":"47","year":"2005","journal-title":"Pediatrics International"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2006.06.023"},{"issue":"11","key":"31","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1093\/jn\/118.11.1391","volume":"118","year":"1988","journal-title":"Journal of Nutrition"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19860070"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/823492.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/823492.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/823492.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T10:17:23Z","timestamp":1565777843000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2014\/823492\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":26,"alternative-id":["823492","823492"],"URL":"https:\/\/doi.org\/10.1155\/2014\/823492","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}