{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:51:03Z","timestamp":1777618263672,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Ten extracts with different polarity from two Iranian<jats:italic>Artemisia<\/jats:italic>species,<jats:italic>A. armeniaca<\/jats:italic>Lam. and<jats:italic>A. aucheri<\/jats:italic>Boiss, were screened for their antimalarial properties by<jats:italic>in vitro<\/jats:italic>\u2009\u2009<jats:italic>\u03b2<\/jats:italic>-hematin formation assay. Dichloromethane (DCM) extracts of both plants showed significant antimalarial activities with IC<jats:sub>50<\/jats:sub>values of 1.36 \u00b1 0.01 and 1.83 \u00b1 0.03\u2009mg\/mL and IC<jats:sub>90<\/jats:sub>values of 2.12 \u00b1 0.04 and 2.62 \u00b1 0.09\u2009mg\/mL for<jats:italic>A. armeniaca<\/jats:italic>and<jats:italic>A. aucheri<\/jats:italic>, respectively. Bioactivity-guided fractionation of DCM extracts of both plants by vacuum liquid chromatography (VLC) over silica gel with solvent mixtures of increasing polarities afforded seven fractions. Two fractions from DCM extract of<jats:italic>A. armeniaca<\/jats:italic>and four fractions from DCM extract of<jats:italic>A. aucheri<\/jats:italic>showed potent antimalarial activity with reducing IC<jats:sub>50<\/jats:sub>and IC<jats:sub>90<\/jats:sub>values compared to extracts. The most potent fraction belonged to DCM extract of<jats:italic>A. armeniaca<\/jats:italic>with IC<jats:sub>50<\/jats:sub>and IC<jats:sub>90<\/jats:sub>values of 0.47 \u00b1 0.006 and 0.71 \u00b1 0.006\u2009mg\/mL, respectively.<\/jats:p>","DOI":"10.1155\/2014\/825370","type":"journal-article","created":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T16:02:31Z","timestamp":1389715351000},"page":"1-6","source":"Crossref","is-referenced-by-count":32,"title":["Evaluation of<i>In Vitro<\/i>Antimalarial Activity of Different Extracts of<i>Artemisia aucheri<\/i>Boiss. and<i>A. armeniaca<\/i>Lam. and Fractions of the Most Potent Extracts"],"prefix":"10.1155","volume":"2014","author":[{"given":"Mahdi","family":"Mojarrab","sequence":"first","affiliation":[{"name":"Novel Drug Delivery Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah 67346-67149, 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