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Mushrooms have been implicated in having preventive effects against chronic diseases due especially to their antioxidant properties. In this study,<jats:italic>in vitro<\/jats:italic>inhibitory effect of<jats:italic>Hericium erinaceus<\/jats:italic>on LDL oxidation and the activity of the cholesterol biosynthetic key enzyme, 3-hydroxy-3-methyl glutaryl coenzyme A (HMG Co-A) reductase, was evaluated using five liquid-liquid solvent fractions consisting of methanol\u2009:\u2009dichloromethane (M\u2009:\u2009DCM), hexane (HEX), dichloromethane (DCM), ethyl acetate (EA), and aqueous residue (AQ). The hexane fraction showed the highest inhibition of oxidation of human LDL as reflected by the increased lag time (100\u2009mins) for the formation of conjugated diene (CD) at 1\u2009\u00b5g\/mL and decreased production (68.28%, IC<jats:sub>50<\/jats:sub>0.73\u2009mg\/mL) of thiobarbituric acid reactive substances (TBARS) at 1\u2009mg\/mL. It also mostly inhibited (59.91%) the activity of the HMG Co-A reductase at 10\u2009mg\/mL. The GC-MS profiling of the hexane fraction identified the presence of myconutrients:<jats:italic>inter alia<\/jats:italic>, ergosterol and linoleic acid. Thus, hexane fraction of<jats:italic>Hericium erinaceus<\/jats:italic>was found to be the most potent<jats:italic>in vitro<\/jats:italic>inhibitor of both LDL oxidation and HMG Co-A reductase activity having therapeutic potential for the prevention of oxidative stress-mediated vascular diseases.<\/jats:p>","DOI":"10.1155\/2014\/828149","type":"journal-article","created":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T21:21:17Z","timestamp":1400016077000},"page":"1-9","source":"Crossref","is-referenced-by-count":38,"title":["Inhibitory Effect on<i>In Vitro<\/i>LDL Oxidation and HMG Co-A Reductase Activity of the Liquid-Liquid Partitioned Fractions of<i>Hericium erinaceus<\/i>(Bull.) 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