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Oral administration of SLEE (30, 100, and 300\u2009mg\/kg) and fruticulin A (0.3 and 3.0\u2009mg\/kg) decreased the total leucocytes number in pleural lavage, protein extravasation, and paw oedema. SLEE (100\u2009mg\/kg) and fruticulin A (3\u2009mg\/kg) also exhibited antihyperalgesic activity in carrageenan induced mechanical hyperalgesia. In addition, fruticulin A (3\u2009mg\/kg) prevented mechanical hyperalgesia, inhibiting TNF but not L\u2010DOPA\u2010induced mechanical hyperalgesia. In conclusion, SLEE and fruticulin A display anti\u2010inflammatory and analgesic properties. Therefore, fruticulin A is at least partially responsible for the activity observed in the ethanolic extract of <jats:italic>Salvia lachnostachys<\/jats:italic>.<\/jats:p>","DOI":"10.1155\/2014\/835914","type":"journal-article","created":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T21:03:39Z","timestamp":1415653419000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Anti\u2010Inflammatory and Antihyperalgesic Activities of Ethanolic Extract and Fruticulin A from <i>Salvia lachnostachys<\/i> Leaves in Mice"],"prefix":"10.1155","volume":"2014","author":[{"given":"Ana Claudia","family":"Piccinelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Figueiredo de Santana Aquino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Neder","family":"Morato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2ngela Midori","family":"Kuraoka-Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regiane Lauriano Batista","family":"Strapasson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9lide Pereira","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria \u00c9lida Alves","family":"Stefanello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Juliano","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e2ndida Aparecida Leite","family":"Kassuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,10]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"crossref","first-page":"10468","DOI":"10.2174\/092986712800229069","article-title":"Anti-inflammatory agents from plants: progress and potential","volume":"19","author":"Recio M. 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