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However, the potency of NJ constituents against LPS\u2010induced inflammatory responses has not been examined. In this present study, we determined which NJ extract fractions exhibit inhibitory effects against LPS\u2010induced inflammatory responses. Among the NJ fractions, NJ\u20101, NJ\u20103, NJ\u20104, and NJ\u20106 inhibited LPS\u2010induced production of NO. The NJ\u20103, NJ\u20104, and NJ\u20106 fractions also inhibited the production of cytokines, such as IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    , IL\u20106, and TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    . However, NJ\u20101, NJ\u20103, NJ\u20104, and NJ\u20106 showed differential inhibitory mechanisms against LPS\u2010induced inflammatory responses. NJ\u20101, NJ\u20103, and NJ\u20104 inhibited LPS\u2010induced activation of c\u2010jun NH\n                    <jats:sub>2<\/jats:sub>\n                    \u2010terminal kinase (JNK) and p38 but did not affect activation of extracellular signal\u2010regulated kinase (ERK) or NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B. On the other hand, NJ\u20106 inhibited activation of MAPKs and NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B. In addition,\n                    <jats:italic>in vivo<\/jats:italic>\n                    experiments revealed that administration of NJ\u20101, NJ\u20103, NJ\u20104, and NJ\u20106 reduced LPS\u2010induced endotoxin shock, with NJ\u20106 especially showing a marked protective effect. Taken together, these results provide the evidence for the potential of selective NJ fractions against LPS\u2010induced inflammation. Thus, it will be advantageous to further isolate and determine single effective compounds from these potent fractions.\n                  <\/jats:p>","DOI":"10.1155\/2014\/837835","type":"journal-article","created":{"date-parts":[[2014,3,30]],"date-time":"2014-03-30T17:05:59Z","timestamp":1396199159000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Beneficial Effects of Fractions of\n                    <i>Nardostachys jatamansi<\/i>\n                    on Lipopolysaccharide\u2010Induced Inflammatory Response"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5627-2676","authenticated-orcid":false,"given":"Gi-Sang","family":"Bae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Ho","family":"Heo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Bok","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il-Joo","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Goo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon-Yeon","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hee","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung-Chel","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Sung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuncheol","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn-Chul","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Joon","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Cheul","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6227-6681","authenticated-orcid":false,"given":"Sung-Joo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,30]]},"reference":[{"key":"e_1_2_9_1_2","first-page":"103","article-title":"Cellular mechanisms of neuroinflammatory pain: the role of interleukin-1\u03b2","volume":"45","author":"Sung C.-S.","year":"2007","journal-title":"Acta Anaesthesiologica Taiwanica"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132532"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202208"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2060"},{"key":"e_1_2_9_5_2","first-page":"799","article-title":"Nardostachys jatamansi DC: a phyto-chemical study of its active constituents","volume":"11","author":"Bose B. 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