{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:31:35Z","timestamp":1773235895002,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Rheumatology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. Increased cardiovascular morbidity and mortality have been observed in ankylosing spondylitis because of accelerated atherosclerosis. We measured carotid intima media thickness (CIMT) as a surrogate marker of atherosclerosis in this study.<jats:italic>Methods<\/jats:italic>. In this study 37 cases of AS and the same number of matched individuals were recruited. CIMT measurements were done using B-mode ultrasound. Disease activity was assessed using Bath ankylosing spondylitis disease activity index (BASDAI), Bath ankylosing spondylitis functional index (BASFI), and Bath ankylosing spondylitis metrological index (BASMI) scores and C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels.<jats:italic>Results<\/jats:italic>. Mean age of the study groups was 29.43\u2009\u00b1\u20099.00 years. Average disease duration was 65.62\u2009\u00b1\u200954.92 months. Twenty-eight (75.68%) of cases were HLA B-27 positive. A significantly increased CIMT was observed in cases as compared to control group (0.62\u2009\u00b1\u20090.12 versus 0.54\u2009\u00b1\u20090.04;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>). CIMT in the cases group positively correlated with age<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mrow><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mrow><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.357<\/mml:mn><mml:mo>;\u2009<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:mrow><\/mml:mrow><\/mml:math>, duration of disease<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mrow><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mrow><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.549<\/mml:mn><mml:mo>;\u2009<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:mrow><\/mml:mrow><\/mml:math>, and BASMI<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mrow><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mrow><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.337<\/mml:mn><mml:mo>;\u2009<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:mrow><\/mml:mrow><\/mml:math>and negatively correlated with ESR<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mrow><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mrow><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>\u2212<\/mml:mo><mml:mn>0.295<\/mml:mn><mml:mo>;\u2009<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:mrow><\/mml:mrow><\/mml:math>.<jats:italic>Conclusions<\/jats:italic>. Patients of AS had a higher CIMT than those of the control group. CIMT correlated with disease chronicity.<\/jats:p>","DOI":"10.1155\/2014\/839135","type":"journal-article","created":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T19:14:29Z","timestamp":1396898069000},"page":"1-5","source":"Crossref","is-referenced-by-count":19,"title":["Carotid Intima Media Thickness as a Marker of Atherosclerosis in Ankylosing Spondylitis"],"prefix":"10.1155","volume":"2014","author":[{"given":"Naveen","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Medicine, SMS Medical College, Jaipur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2850-9290","authenticated-orcid":true,"given":"Renu","family":"Saigal","sequence":"additional","affiliation":[{"name":"Department of Medicine, MG Medical College, Jaipur, India"},{"name":"Rheumatology Clinic, Mahatma Gandhi Medical College and Hospital, 33 Muktanand Nagar, Gopalpura Byepass, Lane in front of Amarnath Hospital, Jaipur 302018, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laxmikant","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Medicine, SMS Medical College, Jaipur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Medicine, SMS Medical College, Jaipur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajat","family":"Bhargava","sequence":"additional","affiliation":[{"name":"Department of Medicine, SMS Medical College, Jaipur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Medicine, SMS Medical College, Jaipur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"2","key":"1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0889-857X(05)70138-1","volume":"26","year":"2000","journal-title":"Rheumatic Disease Clinics of North America"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.06.011"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90551-M"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-002-8271-x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/art.30581"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2004.07.010"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104353"},{"issue":"4","key":"8","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1177\/1759720X13491025","volume":"5","year":"2013","journal-title":"Therapeutic Advances in Musculoskeletal Disease"},{"key":"9","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1016\/j.jacc.2010.09.001","volume":"56","year":"2010","journal-title":"Journal of the American College of Cardiology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901073400103"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.198424"},{"issue":"4","key":"12","doi-asserted-by":"crossref","first-page":"E225","DOI":"10.25011\/cim.v34i4.15364","volume":"34","year":"2011","journal-title":"Clinical and Investigative Medicine"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110792"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken198"},{"issue":"2","key":"15","volume":"131","year":"2013","journal-title":"Sao Paulo Medical Journal"},{"issue":"4","key":"16","doi-asserted-by":"crossref","first-page":"723","DOI":"10.3899\/jrheum.100668","volume":"38","year":"2011","journal-title":"The Journal of Rheumatology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090667"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3181c10773"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0380-5"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2007.11.007"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei145"},{"issue":"4","key":"21","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/acr.20364","volume":"63","year":"2011","journal-title":"Arthritis Care & Research"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1042\/CS20040326"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(03)00287-9"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R300019-JLR200"},{"issue":"4, supplement 55","key":"26","first-page":"S43","volume":"27","year":"2009","journal-title":"Clinical and Experimental Rheumatology"}],"container-title":["International Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijr\/2014\/839135.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijr\/2014\/839135.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijr\/2014\/839135.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T07:10:28Z","timestamp":1498115428000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ijr\/2014\/839135\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":26,"alternative-id":["839135","839135"],"URL":"https:\/\/doi.org\/10.1155\/2014\/839135","relation":{},"ISSN":["1687-9260","1687-9279"],"issn-type":[{"value":"1687-9260","type":"print"},{"value":"1687-9279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}