{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T03:09:04Z","timestamp":1784171344508,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100008189","name":"Deafness Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001537","name":"University of Auckland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>We have previously shown that adenosine amine congener (ADAC), a selective A<jats:sub>1<\/jats:sub>adenosine receptor agonist, can ameliorate noise- and cisplatin-induced cochlear injury. Here we demonstrate the dose-dependent rescue effects of ADAC on noise-induced cochlear injury in a rat model and establish the time window for treatment.<jats:italic>Methods<\/jats:italic>. ADAC (25\u2013300\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>\u03bc<\/mml:mi><\/mml:mrow><\/mml:math>g\/kg) was administered intraperitoneally to Wistar rats (8\u201310 weeks old) at intervals (6\u201372 hours) after exposure to traumatic noise (8\u201316\u2009kHz, 110\u2009dB sound pressure level, 2 hours). Hearing sensitivity was assessed using auditory brainstem responses (ABR) before and 12 days after noise exposure. Pharmacokinetic studies investigated ADAC concentrations in plasma after systemic (intravenous) administration.<jats:italic>Results<\/jats:italic>. ADAC was most effective in the first 24 hours after noise exposure at doses<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mo>&gt;<\/mml:mo><\/mml:mrow><\/mml:math>50\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>\u03bc<\/mml:mi><\/mml:mrow><\/mml:math>g\/kg, providing up to 21\u2009dB protection (averaged across 8\u201328\u2009kHz). Pharmacokinetic studies demonstrated a short (5\u2009min) half-life of ADAC in plasma after intravenous administration without detection of degradation products.<jats:italic>Conclusion<\/jats:italic>. Our data show that ADAC mitigates noise-induced hearing loss in a dose- and time-dependent manner, but further studies are required to establish its translation as a clinical otological treatment.<\/jats:p>","DOI":"10.1155\/2014\/841489","type":"journal-article","created":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T17:19:36Z","timestamp":1409073576000},"page":"1-10","source":"Crossref","is-referenced-by-count":16,"title":["Adenosine Amine Congener as a Cochlear Rescue Agent"],"prefix":"10.1155","volume":"2014","author":[{"given":"Srdjan M.","family":"Vlajkovic","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand"},{"name":"Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New 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