{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:39:39Z","timestamp":1783096779845,"version":"3.54.6"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pathogens"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Helicobacter pylori<\/jats:italic>plays an important role in the pathogenesis of chronic gastritis, peptic ulceration, and noncardia gastric cancer. Several putative virulence factors for<jats:italic>H. pylori<\/jats:italic>have been identified including<jats:italic>vacA<\/jats:italic>,<jats:italic>babA<\/jats:italic>, and<jats:italic>iceA<\/jats:italic>. HopQ is one of the outer membrane proteins involved in bacterial adherence to gastric mucosa and has been suggested to also play a role in the virulence of<jats:italic>H. pylori<\/jats:italic>. Due to the substantial geographic differences in the prevalence of<jats:italic>H. pylori<\/jats:italic>virulence factors reported, the main purpose of the current study was to investigate the association between different<jats:italic>H. pylori<\/jats:italic>virulence<jats:italic>hopQ<\/jats:italic>alleles (types I and II) and patients with gastroduodenal disorders. The presence of<jats:italic>H. pylori<\/jats:italic>and<jats:italic>hopQ<\/jats:italic>alleles in gastric biopsy specimens was identified by specific PCR assays.<jats:italic>H. pylori<\/jats:italic>type II<jats:italic>hopQ<\/jats:italic>was found to be significantly associated with gastric cancer patients (odds ratio: 3.47, 95% CI: 1.56\u20135.89). Information about the prevalence of<jats:italic>H. pylori hopQ<\/jats:italic>type II can be used for determining the high-risk diseases type which is actually colonized by<jats:italic>H. pylori hopQ<\/jats:italic>type II positive strains. The presence of<jats:italic>H. pylori hopQ<\/jats:italic>type II should be investigated in different geographical regions as confirmatory findings may provide a definite biomarker attributed to the pathogenesis of certain severe digestive diseases.<\/jats:p>","DOI":"10.1155\/2014\/842469","type":"journal-article","created":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T16:02:21Z","timestamp":1392048141000},"page":"1-4","source":"Crossref","is-referenced-by-count":10,"title":["High Prevalence of<i>Helicobacter pylori hopQ<\/i>II Genotype Isolated from Iranian Patients with Gastroduodenal Disorders"],"prefix":"10.1155","volume":"2014","author":[{"given":"Amin","family":"Talebi Bezmin Abadi","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Mohabbati Mobarez","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.01.073"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1001110"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1006158"},{"issue":"1","key":"4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/oxfordjournals.bmb.a011662","volume":"54","year":"1998","journal-title":"British Medical Bulletin"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/371503"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-011-0631-6"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2009.00702.x"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-011-0579-6"},{"issue":"2","key":"6","first-page":"93","volume":"67","year":"2013","journal-title":"Acta Medica Okayama"},{"issue":"7","key":"7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/1751-2980.12054","volume":"14","year":"2013","journal-title":"Digestive Diseases"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.05366-0"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.11.016"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0316-9"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-011-0614-7"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2007.05.006"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200209000-00008"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-8244(99)00010-3"},{"issue":"7","key":"15","first-page":"703","volume":"114","year":"2001","journal-title":"Chinese Medical Journal"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsle.2005.07.023"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.12.4504-4511.2002"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2008.01368.x"},{"issue":"10","key":"23","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1097\/00000478-199610000-00001","volume":"20","year":"1996","journal-title":"The American Journal of Surgical Pathology"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00033-06"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00461-10"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00919.x"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2004.11.007"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/01.mog.0000181711.04529.d5"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05762.x"}],"container-title":["Journal of Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jpath\/2014\/842469.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jpath\/2014\/842469.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jpath\/2014\/842469.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T03:37:59Z","timestamp":1498102679000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jpath\/2014\/842469\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":28,"alternative-id":["842469","842469"],"URL":"https:\/\/doi.org\/10.1155\/2014\/842469","relation":{},"ISSN":["2090-3057","2090-3065"],"issn-type":[{"value":"2090-3057","type":"print"},{"value":"2090-3065","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}