{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:25:16Z","timestamp":1772627116679,"version":"3.50.1"},"reference-count":15,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T00:00:00Z","timestamp":1394064000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Rheumatology"],"published-print":{"date-parts":[[2014,3,6]]},"abstract":"<jats:p>HLA-DRB4 gene is associated with Churg-Strauss syndrome (CSS), a systemic eosinophilic vasculitis with a prodromal phase characterized by severe asthma, eosinophilia, nasal polyposis, and sinusitis. Aim of this study was to evaluate if the presence of HLA-DRB4 in asthmatic patients is associated with a clinical picture resembling that of the prodromal phase of CSS. HLA-DRB1 was determined in a cohort of 159 asthmatic patients and its frequency was compared with that of 1808 blood donors. HLA-DRB4 presence\/absence was correlated with clinical features, including sinusitis, nasal polyposis, eosinophils, antiasthmatic drugs, asthma severity, and pulmonary function tests. HLA-DRB4 gene was associated with severe persistent asthma before treatment (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math>), near fatal or severe hypoxemic asthma (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>), sinusitis (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>), nasal polyposis (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>), number of patients with eosinophils &gt;1000\/<jats:italic>\u03bc<\/jats:italic>l: (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>), need of beclomethasone &gt;1000\u20132000\u2009<jats:italic>\u03bc<\/jats:italic>g\/daily (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), use of a third controller (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>), and oral prednisone (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math>). HLA-DRB4 gene is associated in asthmatic patients with a clinical picture characterized by asthma severity, sinusitis, nasal polyposis, and eosinophilia closely resembling that of the prodromal phase of CSS and might be useful to suspect corticosteroids-masked cases of CSS.<\/jats:p>","DOI":"10.1155\/2014\/843804","type":"journal-article","created":{"date-parts":[[2014,3,9]],"date-time":"2014-03-09T09:26:12Z","timestamp":1394357172000},"page":"1-5","source":"Crossref","is-referenced-by-count":4,"title":["Can HLA-DRB4 Help to Identify Asthmatic Patients at Risk of Churg-Strauss Syndrome?"],"prefix":"10.1155","volume":"2014","author":[{"given":"P.","family":"Bottero","sequence":"first","affiliation":[{"name":"Allergy and Clinical Immunology Outpatients Clinic, Azienda Ospedaliera Legnano, Ospedale di Magenta, Via Donatore di Sangue 50, Magenta, 20013 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Motta","sequence":"additional","affiliation":[{"name":"Immunohematology Unit, Azienda Ospedaliera Legnano, Ospedale di Magenta, Via Donatore di sangue 50, Magenta, 20013 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bonini","sequence":"additional","affiliation":[{"name":"Hygienics and Public Health Unit, Azienda Sanitaria Locale Provincia Milano1, Via Spagliardi 19, Parabiago,  20014 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Vecchio","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Outpatients Clinic, Azienda Ospedaliera Legnano, Ospedale di Magenta, Via Donatore di Sangue 50, Magenta, 20013 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Ierna","sequence":"additional","affiliation":[{"name":"Immunohematology Unit, Azienda Ospedaliera Legnano, Ospedale di Magenta, Via Donatore di sangue 50, Magenta, 20013 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Cuppari","sequence":"additional","affiliation":[{"name":"Immunohematology Unit, Azienda Ospedaliera Legnano, Ospedale di Magenta, Via Donatore di sangue 50, Magenta, 20013 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Sinico","sequence":"additional","affiliation":[{"name":"Clinical Immunology Unit and Renal Unit, Department of Medicine, Azienda Ospedaliera Ospedale San Carlo Borromeo, Via Pio Secondo 3, 20153 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3280119854"},{"issue":"6","key":"17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s11739-011-0517-7","volume":"6","year":"2011","journal-title":"Internal and Emergency Medicine"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/art.22834"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/art.23209"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2006.00719.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1080\/02770900701209632"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01023.x"},{"issue":"6","key":"8","first-page":"395","volume":"25","year":"2004","journal-title":"Allergy and Asthma Proceedings"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00830.x"},{"key":"11","first-page":"5","volume":"16","year":"1993","journal-title":"The European Respiratory Journal. Supplement"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200703-456SO"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.01.009"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.07.002"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2007.28.2997"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318159889d"}],"container-title":["ISRN Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/843804.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/843804.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/843804.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T20:50:29Z","timestamp":1607547029000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/isrn\/2014\/843804\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,6]]},"references-count":15,"alternative-id":["843804","843804"],"URL":"https:\/\/doi.org\/10.1155\/2014\/843804","relation":{},"ISSN":["2090-5475"],"issn-type":[{"value":"2090-5475","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,6]]}}}