{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:29:00Z","timestamp":1740169740878,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Department of Biotechnology, Government of India"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Host genetic susceptibility is an important risk factor in infectious diseases. We explored the distribution of Q223R mutation in leptin receptor gene of amoebic liver abscess (ALA) patients of North India. A total of 55 ALA samples along with 102 controls were subjected to PCR-RFLP analysis. The frequency of allele \u201cG\u201d (coding for arginine) was in general high in Indian population irrespective of the disease. Our results of Fisher exact test shows that heterozygous mutant (QQ versus QR,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.049<\/mml:mn><\/mml:math>) and homozygous mutant (QQ versus RR,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.004<\/mml:mn><\/mml:math>) were significantly associated with amoebic liver abscess when compared with homozygous wild (QQ).<\/jats:p>","DOI":"10.1155\/2014\/847132","type":"journal-article","created":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T17:09:03Z","timestamp":1404925743000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["The Trend in Distribution of Q223R Mutation of Leptin Receptor Gene in Amoebic Liver Abscess Patients from North India: A Prospective Study"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3105-4138","authenticated-orcid":true,"given":"Anil Kumar","family":"Verma","sequence":"first","affiliation":[{"name":"School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vineet","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi 110052, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaishree","family":"Paul","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-012-0349-1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003489"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-08"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-3-21"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45294"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/27376"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.40"},{"issue":"5","key":"8","doi-asserted-by":"crossref","first-page":"824","DOI":"10.4269\/ajtmh.2009.80.824","volume":"80","year":"2009","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.3.1215"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2005.02.020"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2005.02.009"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1990.9999"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1136\/adc.87.3.192"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040115"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2010.76"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.06140-11"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01383-12"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/847132.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/847132.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/847132.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T12:12:36Z","timestamp":1565611956000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2014\/847132\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":17,"alternative-id":["847132","847132"],"URL":"https:\/\/doi.org\/10.1155\/2014\/847132","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2014]]}}}