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We explore the relationship between FDG-PET uptake and tumor radioresistance using a mechanistic model that considers cellular status as a function of microenvironmental conditions, including proliferating cells with access to oxygen and glucose, metabolically active cells with access to glucose but not oxygen, and severely hypoxic cells that are starving. However, it is unclear what the precise uptake levels of glucose should be for cells that receive oxygen and glucose versus cells that only receive glucose. Different potential FDG uptake profiles, as a function of the microenvironment, were simulated. Predicted tumor doses for 50% control (TD<jats:sub>50<\/jats:sub>) in 2\u2009Gy fractions were estimated for each assumed uptake profile and for various possible cell mixtures. The results support the hypothesis of an increased avidity of FDG for cells in the intermediate stress state (those receiving glucose but not oxygen) compared to well-oxygenated (and proliferating) cells.<\/jats:p>","DOI":"10.1155\/2014\/847162","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T17:04:20Z","timestamp":1410195860000},"page":"1-7","source":"Crossref","is-referenced-by-count":7,"title":["Modeling the Relationship between Fluorodeoxyglucose Uptake and Tumor Radioresistance as a Function of the Tumor Microenvironment"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5156-5878","authenticated-orcid":true,"given":"Jeho","family":"Jeong","sequence":"first","affiliation":[{"name":"The Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph O.","family":"Deasy","sequence":"additional","affiliation":[{"name":"The Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.2580140204"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.04.019"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.054205"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-010-0972-y"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.01.039"},{"issue":"6","key":"6","doi-asserted-by":"crossref","first-page":"884","DOI":"10.2967\/jnumed.113.133801","volume":"55","year":"2014","journal-title":"Journal of Nuclear Medicine"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i29.4808"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.10.054"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2005.06.014"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.03.018"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1126\/science.123.3191.309"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1478"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1501"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160809"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-0688-3"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.02.009"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-006-0175-6"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2007.349"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-008-0758-5"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31818307a7"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/58\/14\/4897"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1002\/cjce.20204"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.3109\/00313020903488773"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-5472"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2007.04.004"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.2307\/3579620"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2014\/847162.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2014\/847162.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2014\/847162.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T16:06:56Z","timestamp":1498147616000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cmmm\/2014\/847162\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":26,"alternative-id":["847162","847162"],"URL":"https:\/\/doi.org\/10.1155\/2014\/847162","relation":{},"ISSN":["1748-670X","1748-6718"],"issn-type":[{"value":"1748-670X","type":"print"},{"value":"1748-6718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}