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Currently, IFN-<jats:italic>\u03b1<\/jats:italic>has numerous approved antitumor applications, including malignant melanoma, in which IFN-<jats:italic>\u03b1<\/jats:italic>has been shown to increase relapse free survival. Moreover, IFN-<jats:italic>\u03b1<\/jats:italic>has been successfully used in the intralesional treatment of cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). In spite of these promising clinical results; however, there exists a paucity of knowledge on the precise anti-tumor action of IFN-<jats:italic>\u03b1<\/jats:italic>\/<jats:italic>\u03b2<\/jats:italic>at the cellular and molecular levels in cutaneous malignancies such as SCC, BCC, and melanoma. This review summarizes current knowledge on the extent to which Type I IFN influences proliferation, apoptosis, angiogenesis, and immune function in normal skin, cutaneous SCC, BCC, and melanoma.<\/jats:p>","DOI":"10.1155\/2014\/847545","type":"journal-article","created":{"date-parts":[[2014,1,5]],"date-time":"2014-01-05T21:01:44Z","timestamp":1388955704000},"page":"1-11","source":"Crossref","is-referenced-by-count":24,"title":["Type I Interferons: Key Players in Normal Skin and Select Cutaneous Malignancies"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4584-1500","authenticated-orcid":true,"given":"Aimen","family":"Ismail","sequence":"first","affiliation":[{"name":"School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, 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