{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:29:07Z","timestamp":1740169747243,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Pemphigus is an autoimmune blistering disease mediated by autoantibodies directed against keratinocyte adhesion molecules. Leptin, an adipocyte-derived hormone, plays a role in immune responses and promotes autoimmunity.<jats:italic>Objectives<\/jats:italic>. This study was conducted to determine whether serum leptin levels are altered in pemphigus patients and whether there is any correlation between leptin levels and the severity of disease.<jats:italic>Methods<\/jats:italic>. This study included 47 newly diagnosed patients with pemphigus and 43 age- and sex-matched healthy controls. Clinical characteristics and pemphigus area and activity score (PAAS) were assessed. Serum leptin levels (ng\/mL) were measured by a commercial enzyme-linked immunosorbent assay (ELISA).<jats:italic>Results<\/jats:italic>. Patients did not differ significantly in serum leptin levels from healthy controls (median (range): 10.8 (0.1\u2013110)\u2009ng\/mL versus 12 (0.5\u201369.9)\u2009ng\/mL and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.53<\/mml:mn><\/mml:math>). There was no significant association between serum leptin concentrations and severity of disease measured by PAAS (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:msub><mml:mrow><mml:mi>r<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi>s<\/mml:mi><\/mml:mrow><\/mml:msub><mml:mo>=<\/mml:mo><mml:mn>0.06<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.70<\/mml:mn><\/mml:math>).<jats:italic>Conclusion<\/jats:italic>. The results suggest that pemphigus does not have a direct influence on serum leptin levels and the pathogenesis of pemphigus seems to be not dependent on the connection with adipose tissue.<\/jats:p>","DOI":"10.1155\/2014\/853705","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T17:06:09Z","timestamp":1399914369000},"page":"1-5","source":"Crossref","is-referenced-by-count":3,"title":["Serum Leptin Levels in Pemphigus: A Case Control Study"],"prefix":"10.1155","volume":"2014","author":[{"given":"Nikoo","family":"Mozafari","sequence":"first","affiliation":[{"name":"Skin Research Center, Department of Dermatology, Shahid Beheshti University of Medical Sciences, Shohada-e-Tajrish Hospital, Shahrdari Street, Tehran 1989934148, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza M.","family":"Robati","sequence":"additional","affiliation":[{"name":"Skin Research Center, Department of Dermatology, Shahid Beheshti University of Medical Sciences, Shohada-e-Tajrish Hospital, Shahrdari Street, Tehran 1989934148, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shima","family":"Younespour","sequence":"additional","affiliation":[{"name":"Skin Research Center, Department of Dermatology, Shahid Beheshti University of Medical Sciences, Shohada-e-Tajrish Hospital, Shahrdari Street, Tehran 1989934148, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2004"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2011.10.012"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2010.75"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2006.09.006"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66829-8"},{"issue":"11","key":"6","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/exd.12229","volume":"22","year":"2013","journal-title":"Experimental Dermatology"},{"issue":"1","key":"7","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s10875-011-9597-4","volume":"32","year":"2012","journal-title":"Journal of Clinical Immunology"},{"issue":"2","key":"8","first-page":"158","volume":"37","year":"1998","journal-title":"International Journal of Dermatology"},{"issue":"3","key":"9","first-page":"239","volume":"46","year":"2008","journal-title":"Acta Medica Iranica"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-014-1072-9"},{"issue":"1","key":"11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1590\/S0036-46651995000100008","volume":"37","year":"1995","journal-title":"Revista do Instituto de Medicina Tropical de Sao Paulo"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2001.01266.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2007.02390.x"},{"issue":"1","key":"14","first-page":"1","volume":"4","year":"2007","journal-title":"Cellular & Molecular Immunology"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/568343"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2174\/092986707780362826"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-002-0216-9"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309350321"},{"issue":"2","key":"19","first-page":"e25","volume":"12","year":"2013","journal-title":"Journal of Drugs in Dermatology"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2007.00886.x"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/853705.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/853705.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/853705.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T09:05:07Z","timestamp":1498122307000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2014\/853705\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":20,"alternative-id":["853705","853705"],"URL":"https:\/\/doi.org\/10.1155\/2014\/853705","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2014]]}}}