{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T07:28:52Z","timestamp":1648711732843},"reference-count":23,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Cardiology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Familial hypercholesterolemia (FH) is an inherited metabolic disorder characterized by elevated low-density lipoprotein cholesterol levels in the blood. In its heterozygous form, it occurs in 1 in 500 individuals in the general population. It is an important contributor to the early onset of coronary artery disease (CAD), accounting for 5\u201310% of cases of cardiovascular events in people younger than 50 years. Atherogenesis triggered by hypercholesterolemia generally progresses faster in the coronary arteries, followed by the subsequent involvement of other arteries such as the carotids. Thus, symptoms of CAD commonly appear before the onset of significant carotid stenosis. Herein, we report the case of a patient with untreated FH who had severe carotid atherosclerosis at the age of 46 years but had no evidence of significant CAD.<\/jats:p>","DOI":"10.1155\/2014\/853921","type":"journal-article","created":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T17:59:14Z","timestamp":1414087154000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Severe Carotid Stenosis in a Patient with Familial Hypercholesterolemia without Significant Coronary Artery Disease"],"prefix":"10.1155","volume":"2014","author":[{"given":"Marcos Aur\u00e9lio Lima","family":"Barros","sequence":"first","affiliation":[{"name":"Marcor Clinic, Maximum Body Care and Recovery, Avenida Presidente Vargas 811, 64200-200 Parna\u00edba, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hygor","family":"Ferreira-Fernandes","sequence":"additional","affiliation":[{"name":"Genetics and Molecular Biology Laboratory, Federal University of Piau\u00ed, Avenida S\u00e3o Sebasti\u00e3o 2819, 64202-020 Parna\u00edba, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid Cristina R\u00eago","family":"Barros","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Federal University of Piau\u00ed, Avenida S\u00e3o Sebasti\u00e3o 2819, 64202-020 Parna\u00edba, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriel R\u00eago","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Federal University of Piau\u00ed, R. 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