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PAI-1 plays a pivotal role in acute thrombotic events such as deep vein thrombosis (DVT) and myocardial infarction (MI). The biological effects of PAI-1 extend far beyond thrombosis including its critical role in fibrotic disorders, atherosclerosis, renal and pulmonary fibrosis, type-2 diabetes, and cancer. The conversion of PAI-1 from the active to the latent conformation appears to be unique among serpins in that it occurs spontaneously at a relatively rapid rate. Latency transition is believed to represent a regulatory mechanism, reducing the risk of thrombosis from a prolonged antifibrinolytic action of PAI-1. Thus, relying solely on plasma concentrations of PAI-1 without assessing its function may be misleading in interpreting the role of PAI-1 in many complex diseases. Environmental conditions, interaction with other proteins, mutations, and glycosylation are the main factors that have a significant impact on the stability of the PAI-1 structure. This review provides an overview on the current knowledge on PAI-1 especially importance of PAI-1 level and stability and highlights the potential use of PAI-1 inhibitors for treating cardiovascular disease.<\/jats:p>","DOI":"10.1155\/2014\/858293","type":"journal-article","created":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T21:11:36Z","timestamp":1413407496000},"page":"1-11","source":"Crossref","is-referenced-by-count":72,"title":["Functional Stability of Plasminogen Activator Inhibitor-1"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8875-3637","authenticated-orcid":true,"given":"Songul","family":"Yasar Yildiz","sequence":"first","affiliation":[{"name":"Department of Bioengineering, Marmara University, 34722 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinar","family":"Kuru","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Marmara University, Selimiye M. 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