{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:18:46Z","timestamp":1783466326768,"version":"3.55.0"},"reference-count":16,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T00:00:00Z","timestamp":1390348800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Neurology"],"published-print":{"date-parts":[[2014,1,22]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Multiple sclerosis (MS) therapeutics entered a new era after the development of anti-JC virus (anti-JCV) antibody assay that assesses the risk of development of progressive multifocal leukoencephalopathy (PML) in patients treated with natalizumab. <jats:italic>Objective<\/jats:italic>. To determine the prevalence of anti-JCV antibody among MS patients in Kuwait. <jats:italic>Methods<\/jats:italic>. Using the national MS registry, demographics and disease characteristics of MS patients who were screened for anti-JC virus antibody were collected. The prevalence of anti-JCV antibody seropositivity and its association with demographic and disease characteristics were evaluated. <jats:italic>Results<\/jats:italic>. Out of 110 screened MS patients for anti-JCV antibodies, 65.5% were females. Mean age and disease duration were 29.23\u2009\u00b1\u20098.55 and 5.39\u2009\u00b1\u20095.04 years, respectively. 47.3% of patients were already on natalizumab and 52.7% of patients were screened for stratification to either natalizumab or a different Disease Modifying Therapy (DMT). The overall prevalence of anti-JC virus antibody was 40%. Gender (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.69<\/mml:mn><\/mml:mrow><\/mml:math>), disease duration (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.11<\/mml:mn><\/mml:mrow><\/mml:math>), and number of natalizumab infusions (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.64<\/mml:mn><\/mml:mrow><\/mml:math>) were not associated with seropositivity. Patients aged \u226530 years were more likely to be seropositive (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><\/mml:math>). <jats:italic>Conclusion<\/jats:italic>. The prevalence of anti-JCV antibody is slightly lower than what is reported in published studies. Seropositivity was associated with an increasing age of MS patients.<\/jats:p>","DOI":"10.1155\/2014\/861091","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T06:27:50Z","timestamp":1390458470000},"page":"1-4","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence of Anti-JC Virus Antibody in Multiple Sclerosis Patients in Kuwait"],"prefix":"10.1155","volume":"2014","author":[{"given":"S.","family":"Lamdhade","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Medicine, Amiri Hospital, Arabian Gulf Street, 13041 Kuwait City, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ashkanani","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Amiri Hospital, Arabian Gulf Street, 13041 Kuwait City, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Alroughani","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Amiri Hospital, Arabian Gulf Street, 13041 Kuwait City, Kuwait"},{"name":"Neurology Clinic, Dasman Diabetes Institute, P.O. Box 1180, 15462 Dasman, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054693"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22606"},{"key":"3","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1212\/WNL.0b013e3182583022","volume":"78","year":"2012","journal-title":"Neurology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513477925"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513504328"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jcv.2013.02.002","volume":"57","year":"2013","journal-title":"Journal of Clinical Virology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1086\/597126"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.020115-0"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000257832.38943.2b"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22128"},{"key":"13","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1177\/1352458511429955","volume":"18","year":"2012","journal-title":"Multiple Sclerosis"},{"key":"14","volume":"78","year":"2012","journal-title":"Neurology"},{"key":"15","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s13365-012-0107-0","volume":"18","year":"2012","journal-title":"Journal of NeuroVirology"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511435105"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22107"}],"container-title":["ISRN Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/861091.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/861091.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/861091.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T21:01:29Z","timestamp":1607547689000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/isrn\/2014\/861091\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,22]]},"references-count":16,"alternative-id":["861091","861091"],"URL":"https:\/\/doi.org\/10.1155\/2014\/861091","relation":{},"ISSN":["2090-5513"],"issn-type":[{"value":"2090-5513","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,22]]}}}