{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:38:02Z","timestamp":1761597482059,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. Warm hepatic ischemia-reperfusion (I\/R) injury can lead to multiorgan dysfunction. The aim of the present study was to investigate whether acute liver I\/R does affect the function and\/or structure of remote organs such as lung, kidney, and heart via modulation of extracellular matrix remodelling.<jats:italic>Methods<\/jats:italic>. Male Sprague-Dawley rats were subjected to 30\u2009min partial hepatic ischemia by clamping the hepatic artery and the portal vein. After a 60\u2009min reperfusion, liver, lung, kidney, and heart biopsies and blood samples were collected. Serum hepatic enzymes, creatinine, urea, Troponin I and TNF-alpha, and tissue matrix metalloproteinases (MMP-2, MMP-9), myeloperoxidase (MPO), malondialdehyde (MDA), and morphology were monitored.<jats:italic>Results<\/jats:italic>. Serum levels of hepatic enzymes and TNF-alpha were concomitantly increased during hepatic I\/R. An increase in hepatic MMP-2 and MMP-9 activities was substantiated by tissue morphology alterations. Notably, acute hepatic I\/R affect the lung inasmuch as MMP-9 activity and MPO levels were increased. No difference in MMPs and MPO was observed in kidney and heart.<jats:italic>Conclusions<\/jats:italic>. Although the underlying mechanism needs further investigation, this is the first study in which the MMP activation in a distant organ is reported; this event is probably TNF-alpha-mediated and the lung appears as the first remote organ to be involved in hepatic I\/R injury.<\/jats:p>","DOI":"10.1155\/2014\/867548","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T22:43:00Z","timestamp":1390516980000},"page":"1-10","source":"Crossref","is-referenced-by-count":9,"title":["Lung Matrix Metalloproteinase Activation following Partial Hepatic Ischemia\/Reperfusion Injury in Rats"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1312-7513","authenticated-orcid":true,"given":"Giuseppina","family":"Palladini","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Via Ferrata 9A, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ferrigno","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Via Ferrata 9A, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittoria","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Fondazione IRCCS Policlinico S. Matteo, University of Pavia, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Tarantola","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology \u201cLazzaro Spallanzani,\u201d University of Pavia, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5987-4373","authenticated-orcid":true,"given":"Vittorio","family":"Bertone","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology \u201cLazzaro Spallanzani,\u201d University of Pavia, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4452-137X","authenticated-orcid":true,"given":"Isabel","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology \u201cLazzaro Spallanzani,\u201d University of Pavia, 27100 Pavia, Italy"},{"name":"Institute of Molecular Genetics of the C.N.R. (IGM-CNR), Histochemistry and Cytometry Section, University of Pavia, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0320-8574","authenticated-orcid":true,"given":"Stefano","family":"Perlini","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Via Ferrata 9A, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1068-6854","authenticated-orcid":true,"given":"Plinio","family":"Richelmi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Via Ferrata 9A, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2464-6127","authenticated-orcid":true,"given":"Mariapia","family":"Vairetti","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Via Ferrata 9A, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"year":"1999","key":"1"},{"issue":"3","key":"2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<255::AID-PATH526>3.0.CO;2-6","volume":"190","year":"2000","journal-title":"Journal of Pathology"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1016\/j.transproceed.2006.05.002"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.1007\/s11605-007-0252-6"},{"doi-asserted-by":"publisher","key":"5","DOI":"10.1097\/00003246-199706000-00023"},{"issue":"6","key":"6","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/S0002-9440(10)61160-1","volume":"160","year":"2002","journal-title":"American Journal of Pathology"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1016\/j.surg.2006.03.024"},{"issue":"1","key":"8","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1172\/JCI117630","volume":"95","year":"1995","journal-title":"Journal of Clinical Investigation"},{"doi-asserted-by":"publisher","key":"9","DOI":"10.1016\/S0168-8278(99)80007-5"},{"key":"10","first-page":"145","volume":"78","year":"1999","journal-title":"Advances in Cancer Research"},{"doi-asserted-by":"publisher","key":"11","DOI":"10.2353\/ajpath.2007.060456"},{"doi-asserted-by":"publisher","key":"12","DOI":"10.1016\/j.transproceed.2003.10.049"},{"doi-asserted-by":"publisher","key":"13","DOI":"10.1097\/01.TP.0000131170.67671.75"},{"doi-asserted-by":"publisher","key":"14","DOI":"10.1111\/j.1572-0241.2004.04055.x"},{"doi-asserted-by":"publisher","key":"15","DOI":"10.1007\/s10157-004-0289-8"},{"doi-asserted-by":"publisher","key":"16","DOI":"10.1007\/s10495-005-6061-z"},{"doi-asserted-by":"publisher","key":"17","DOI":"10.1097\/00000539-199806000-00009"},{"key":"18","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1177\/0192623312441403","volume":"40","year":"2012","journal-title":"Toxicologic Pathology"},{"issue":"4","key":"19","first-page":"G567","volume":"251","year":"1986","journal-title":"American Journal of Physiology: Gastrointestinal and Liver Physiology"},{"issue":"6","key":"20","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/S0002-9440(10)65703-3","volume":"153","year":"1998","journal-title":"American Journal of Pathology"},{"issue":"1","key":"21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","year":"1951","journal-title":"The Journal of Biological Chemistry"},{"doi-asserted-by":"publisher","key":"22","DOI":"10.1097\/00004872-200309000-00022"},{"issue":"5","key":"23","doi-asserted-by":"crossref","first-page":"H1516","DOI":"10.1152\/ajpheart.1998.274.5.H1516","volume":"274","year":"1998","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"doi-asserted-by":"publisher","key":"24","DOI":"10.1006\/abio.1994.1186"},{"doi-asserted-by":"publisher","key":"25","DOI":"10.1007\/BF00714328"},{"doi-asserted-by":"publisher","key":"26","DOI":"10.1016\/j.amjhyper.2007.01.016"},{"doi-asserted-by":"publisher","key":"27","DOI":"10.1002\/hep.20089"},{"doi-asserted-by":"publisher","key":"28","DOI":"10.1152\/ajpheart.01362.2005"},{"doi-asserted-by":"publisher","key":"29","DOI":"10.1002\/hep.21922"},{"doi-asserted-by":"publisher","key":"30","DOI":"10.2353\/ajpath.2009.080872"},{"issue":"2","key":"31","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00024382-199808000-00001","volume":"10","year":"1998","journal-title":"Shock"},{"doi-asserted-by":"publisher","key":"32","DOI":"10.1016\/S0022-3468(98)90460-2"},{"doi-asserted-by":"publisher","key":"33","DOI":"10.1159\/000046165"},{"doi-asserted-by":"publisher","key":"34","DOI":"10.1002\/path.1491"},{"doi-asserted-by":"publisher","key":"35","DOI":"10.1016\/j.cardiores.2005.12.002"},{"issue":"6","key":"36","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/jlb.56.6.672","volume":"56","year":"1994","journal-title":"Journal of Leukocyte Biology"},{"doi-asserted-by":"publisher","key":"37","DOI":"10.1016\/j.freeradbiomed.2005.02.004"},{"doi-asserted-by":"publisher","key":"38","DOI":"10.1016\/j.transproceed.2010.02.097"},{"issue":"1","key":"39","first-page":"29","volume":"6","year":"2001","journal-title":"Experimental and Clinical Cardiology"},{"doi-asserted-by":"publisher","key":"40","DOI":"10.1007\/s11010-011-1066-0"},{"doi-asserted-by":"publisher","key":"41","DOI":"10.1007\/s00011-012-0446-6"}],"container-title":["The Scientific World Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2014\/867548.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2014\/867548.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2014\/867548.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T10:33:52Z","timestamp":1648118032000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/tswj\/2014\/867548\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":41,"alternative-id":["867548","867548"],"URL":"https:\/\/doi.org\/10.1155\/2014\/867548","relation":{},"ISSN":["2356-6140","1537-744X"],"issn-type":[{"type":"print","value":"2356-6140"},{"type":"electronic","value":"1537-744X"}],"subject":[],"published":{"date-parts":[[2014]]}}}