{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T12:05:57Z","timestamp":1792325157394,"version":"4.4.0"},"reference-count":311,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Present review highlights various drug delivery systems used for delivery of pharmaceutical agents mainly antibiotics, antineoplastic agents, neuropeptides, and other therapeutic substances through the endothelial capillaries (BBB) for CNS therapeutics. In addition, the use of ultrasound in delivery of therapeutic agents\/biomolecules such as proline rich peptides, prodrugs, radiopharmaceuticals, proteins, immunoglobulins, and chimeric peptides to the target sites in deep tissue locations inside tumor sites of brain has been explained. In addition, therapeutic applications of various types of nanoparticles such as chitosan based nanomers, dendrimers, carbon nanotubes, niosomes, beta cyclodextrin carriers, cholesterol mediated cationic solid lipid nanoparticles, colloidal drug carriers, liposomes, and micelles have been discussed with their recent advancements. Emphasis has been given on the need of physiological and therapeutic optimization of existing drug delivery methods and their carriers to deliver therapeutic amount of drug into the brain for treatment of various neurological diseases and disorders. Further, strong recommendations are being made to develop nanosized drug carriers\/vehicles and noninvasive therapeutic alternatives of conventional methods for better therapeutics of CNS related diseases. Hence, there is an urgent need to design nontoxic biocompatible drugs and develop noninvasive delivery methods to check posttreatment clinical fatalities in neuropatients which occur due to existing highly toxic invasive drugs and treatment methods.<\/jats:p>","DOI":"10.1155\/2014\/869269","type":"journal-article","created":{"date-parts":[[2014,7,20]],"date-time":"2014-07-20T21:07:00Z","timestamp":1405890420000},"page":"1-37","source":"Crossref","is-referenced-by-count":422,"title":["Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier"],"prefix":"10.1155","volume":"2014","author":[{"given":"Ravi Kant","family":"Upadhyay","sequence":"first","affiliation":[{"name":"Department of Zoology, DDU Gorakhpur University, Gorakhpur 273009, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/RMR.0b013e3180332e79"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-007-9379-0"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2174\/1389201013378734"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.43.100901.140204"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2003.08.003"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2174\/156802611797183230"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.1.68"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2011.06.027"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/0169-409X(96)00011-7"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-008-9018-7"},{"issue":"15","key":"11","first-page":"1563","volume":"129","year":"2013","journal-title":"Duodecim"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.12.86"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.4155\/tde.10.43"},{"issue":"8","key":"14","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.ijdevneu.2013.10.005","volume":"31","year":"2013","journal-title":"International Journal of Developmental Neuroscience"},{"issue":"4","key":"15","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1503\/cmaj.060038","volume":"174","year":"2006","journal-title":"Canadian Medical Association Journal"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2013.08.008"},{"key":"17","year":"2014","journal-title":"ACS Nano"},{"issue":"116","key":"18","first-page":"17","volume":"1","year":"2014","journal-title":"Colloids and Surfaces B: Biointerfaces"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1039\/c1ob05757j"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1358\/dnp.2003.16.5.878815"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.301.3.838"},{"issue":"24","key":"22","first-page":"8899","volume":"63","year":"2003","journal-title":"Cancer Research"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043384916"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.3171\/2011.10.FOCUS11252"},{"issue":"1, article e4","key":"25","volume":"32","year":"2012","journal-title":"Neurosurgical focus"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-008-0036-8"},{"issue":"3","key":"27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/107327480401100304","volume":"11","year":"2004","journal-title":"Cancer Control"},{"issue":"3","key":"28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF00165526","volume":"11","year":"1991","journal-title":"Journal of Neuro-Oncology"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noq161"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.99.4.0728"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.11.028"},{"issue":"2","key":"32","first-page":"21","volume":"84","year":"2001","journal-title":"Consumers' Research Magazine"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.2174\/138161209788682523"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2468"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(13)71253-2"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-008-9009-8"},{"issue":"8","key":"37","first-page":"736","volume":"7","year":"2004","journal-title":"IDrugs"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1021\/ol0351044"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwt059"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2012.06.008"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011981927620"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022482604276"},{"issue":"5","key":"43","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1046\/j.1471-4159.1998.70051781.x","volume":"70","year":"1998","journal-title":"Journal of Neurochemistry"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100054062"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.2174\/138161210791164108"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2007.03.025"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(94)90391-3"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1979.00790160014003"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1211\/0022357022539"},{"issue":"2","key":"50","first-page":"56","volume":"51","year":"2004","journal-title":"Anesthesia Progress"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-008-9144-7"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.2741\/2267"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.2741\/2443"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.2174\/1567201053586047"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2009.103"},{"issue":"9","key":"56","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S0196-0644(05)80657-2","volume":"21","year":"1992","journal-title":"Annals of Emergency Medicine"},{"key":"57","series-title":"Drugs and the Pharmaceutical Sciences","year":"1989"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1039\/c3dt52647j"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(02)00136-9"},{"issue":"1","key":"67","first-page":"92","volume":"21","year":"2012","journal-title":"Nigerian Journal of Medicine"},{"key":"116","doi-asserted-by":"publisher","DOI":"10.1002\/bit.21764"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20130484"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1691\/ph.2013.1148"},{"issue":"2","key":"59","first-page":"102","volume":"9","year":"2013","journal-title":"Current Diabetes Reviews"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3123"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0474"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000240"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00368.2012"},{"key":"64"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-012-9784-z"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1159\/000342492"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2013.748746"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.09.072"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.2174\/09298673130113"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.02.071"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1021\/mp300391v"},{"issue":"24","key":"73","first-page":"6159","volume":"59","year":"1999","journal-title":"Cancer Research"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1021\/bc9901393"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1021\/bc980123x"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-014-0719-2"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1021\/mp400642s"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.3161"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.3149"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.3019"},{"issue":"4","key":"81","first-page":"181","volume":"6","year":"2013","journal-title":"Current Radiopharmaceuticals"},{"issue":"4","key":"83","first-page":"1074","volume":"18","year":"2013","journal-title":"Journal of BUON"},{"issue":"4","key":"84","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/MNM.0000000000000065","volume":"35","year":"2014","journal-title":"Nuclear Medicine Communications"},{"key":"85","year":"2013","journal-title":"Molecular Pharmaceutics"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72117"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc45928d"},{"issue":"10","key":"89","first-page":"4219","volume":"33","year":"2013","journal-title":"Anticancer Res"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)03108-5"},{"issue":"12","key":"91","first-page":"1753","volume":"3","year":"2002","journal-title":"Current Opinion in Investigational Drugs"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.1.254"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.37.1.239"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012117815460"},{"issue":"9","key":"95","first-page":"79","volume":"16","year":"2002","journal-title":"Oncology"},{"issue":"2","key":"96","first-page":"105","volume":"22","year":"2004","journal-title":"Restorative Neurology and Neuroscience"},{"issue":"9, supplement 10","key":"97","first-page":"91","volume":"16","year":"2002","journal-title":"Oncology"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-010-0775-6"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.187"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-386986-9.00002-8"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2011.1922"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.09.010"},{"key":"104","doi-asserted-by":"publisher","DOI":"10.1039\/b816577g"},{"key":"105","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2009.07.016"},{"key":"106","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2007.0466"},{"key":"107","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-013-8401-2"},{"key":"108","doi-asserted-by":"publisher","DOI":"10.1021\/cr000700m"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.1021\/mp900103n"},{"key":"110","doi-asserted-by":"publisher","DOI":"10.3109\/10611860008997918"},{"key":"111","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.01.061"},{"key":"112","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-5-4"},{"key":"113","doi-asserted-by":"publisher","DOI":"10.1021\/bc200174x"},{"key":"114","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2008.12.002"},{"key":"117","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(00)00139-3"},{"key":"118","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.200300079"},{"key":"119","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(08)60411-8"},{"key":"120","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2005.07.010"},{"key":"121","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.06.046"},{"key":"122","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.105.3.445"},{"key":"123","doi-asserted-by":"publisher","DOI":"10.3171\/2011.10.FOCUS11238"},{"key":"124","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(01)00299-1"},{"key":"125","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.01.099"},{"key":"126","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-2609"},{"key":"127","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.03.043"},{"key":"128","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2011.06.013"},{"key":"129","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-012-0117-8"},{"key":"130","doi-asserted-by":"publisher","DOI":"10.1080\/10590501.2013.829706"},{"key":"131","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-12-82"},{"key":"132","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.06.043"},{"key":"133","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02038-7"},{"key":"134","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025053115583"},{"key":"136","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100054062"},{"key":"137","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-8-22"},{"key":"138"},{"key":"139","doi-asserted-by":"publisher","DOI":"10.1124\/mi.10.5.6"},{"key":"140","doi-asserted-by":"publisher","DOI":"10.1177\/0284185113517115"},{"key":"141","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01156.2013"},{"key":"142","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2013.10.017"},{"key":"143","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2013.10.022"},{"key":"144","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2013.11.011"},{"key":"145","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.19.1.016005"},{"key":"146","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2014.868434"},{"key":"147","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2013.11.002"},{"key":"148","first-page":"37","volume":"44","year":"2013","journal-title":"Computers in Biology and Medicine"},{"key":"149","doi-asserted-by":"publisher","DOI":"10.3233\/THC-130772"},{"key":"150","doi-asserted-by":"publisher","DOI":"10.2174\/1389201014666131226114611"},{"issue":"1","key":"151","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1248\/bpb.b13-00605","volume":"37","year":"2014","journal-title":"Biological Pharmaceutical Bulletin"},{"issue":"4","key":"152","first-page":"399","volume":"21","year":"2013","journal-title":"Protein Peptide Letters"},{"key":"153","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002411"},{"key":"154","doi-asserted-by":"publisher","DOI":"10.1021\/jf903529m"},{"key":"155","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.19.1166"},{"issue":"11","key":"156","first-page":"656","volume":"12","year":"1992","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"157","doi-asserted-by":"publisher","DOI":"10.1179\/174313209X385617"},{"key":"158","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2008.12.006"},{"key":"159","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-009-9279-1"},{"key":"160","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.175"},{"key":"161","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32832c4af0"},{"key":"162","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.02.023"},{"key":"163","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v19.i2.10"},{"key":"164","doi-asserted-by":"publisher","DOI":"10.4155\/tde.11.156"},{"key":"165","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.06.002"},{"key":"166","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(01)00245-9"},{"key":"167","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.11.033"},{"key":"168","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.addr.2013.08.008","volume":"71","year":"2014","journal-title":"Advances in Drug Delivery Reviews"},{"key":"169","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(03)00041-3"},{"key":"170","doi-asserted-by":"publisher","DOI":"10.1021\/bm0503221"},{"issue":"5","key":"171","first-page":"375","volume":"61","year":"2006","journal-title":"Pharmazie"},{"key":"172","doi-asserted-by":"publisher","DOI":"10.1124\/mol.110.063685"},{"key":"173","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2009.06.008"},{"key":"174","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(00)00339-4"},{"key":"175","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-013-4993-3"},{"key":"176","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2004.08.010"},{"key":"177","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018955631835"},{"key":"178","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.06.002"},{"key":"179","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.05.010"},{"key":"180","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2004.03.028"},{"issue":"2, article e20","key":"181","volume":"56","year":"2012","journal-title":"European Journal of Histochemistry"},{"key":"182","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057094"},{"key":"183","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-011-9716-9"},{"key":"184","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001894"},{"key":"185","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-011-9647-5"},{"key":"186","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-010-9561-2"},{"key":"187","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S26365"},{"key":"188","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S26571"},{"key":"189","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2009.11.002"},{"key":"190","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S40519"},{"key":"191","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.399"},{"key":"192","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S34348"},{"key":"193","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S39615"},{"key":"194","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.06.019"},{"key":"195","first-page":"485","volume":"6","year":"2011","journal-title":"International Journal of Nanomedicine"},{"key":"196","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S39685"},{"key":"197","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-012-9854-8"},{"key":"198","first-page":"1963","volume":"6","year":"2011","journal-title":"International Journal of Nanomedicine"},{"key":"199","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2012.677028"},{"key":"200","first-page":"765","volume":"6","year":"2011","journal-title":"International Journal of Nanomedicine"},{"key":"201","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S30919"},{"key":"202","first-page":"3351","volume":"6","year":"2011","journal-title":"International Journal of Nanomedicine"},{"key":"203","doi-asserted-by":"publisher","DOI":"10.1021\/bm801026k"},{"key":"204","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2013.24"},{"key":"205","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-009-9375-2"},{"key":"206","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.04.019"},{"key":"207","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-011-9584-3"},{"key":"208","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-008-9042-z"},{"key":"209","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-010-9412-1"},{"key":"210","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-010-9555-0"},{"key":"211","doi-asserted-by":"publisher","DOI":"10.2174\/09298673113209990115"},{"key":"212","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-010-9448-2"},{"key":"213","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-012-0700-1"},{"key":"214","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-011-9685-z"},{"key":"215","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.05.010"},{"key":"216","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2010.03.003"},{"key":"218","year":"2012"},{"issue":"2","key":"219","first-page":"121","volume":"65","year":"2013","journal-title":"Brain and Nerve"},{"key":"220","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062241"},{"key":"221","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v26.i6.10"},{"issue":"4","key":"222","first-page":"595","volume":"2","year":"2007","journal-title":"International Journal of Nanomedicine"},{"key":"223","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-012-9377-y"},{"key":"224","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14011629"},{"key":"225","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121423109"},{"key":"226","doi-asserted-by":"publisher","DOI":"10.3109\/09687688.2010.522203"},{"key":"227","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq921"},{"key":"228","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S40579"},{"key":"229","doi-asserted-by":"publisher","DOI":"10.3109\/09687688.2010.507788"},{"key":"230","doi-asserted-by":"publisher","DOI":"10.4155\/tde.12.127"},{"key":"231","doi-asserted-by":"publisher","DOI":"10.1021\/bc900150v"},{"key":"232","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023134"},{"key":"233","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2011.05.005"},{"key":"234","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-010-0364-7"},{"key":"235","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2013.11.050"},{"key":"236","doi-asserted-by":"publisher","DOI":"10.1002\/btpr.1834"},{"key":"237","doi-asserted-by":"publisher","DOI":"10.2174\/138955712798868959"},{"key":"238","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2010.12.009"},{"key":"239","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21270"},{"key":"240","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.11.056"},{"key":"241","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S23696"},{"key":"242","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2013.12.008"},{"key":"243","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.136"},{"key":"244","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011085"},{"key":"245","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2011.10.028"},{"key":"246","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.01.019"},{"key":"247","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.12.029"},{"key":"248","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.11.005"},{"key":"249","doi-asserted-by":"publisher","DOI":"10.4161\/bioe.27339"},{"key":"250","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.01.012"},{"issue":"2","key":"251","first-page":"169","volume":"6","year":"2014","journal-title":"The American Journal of Translational Research"},{"key":"252","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-009-9140-1"},{"key":"253","doi-asserted-by":"publisher","DOI":"10.1016\/S1461-5347(00)00255-8"},{"key":"254","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/(SICI)1098-2299(199903\/04)46:3\/4<316::AID-DDR18>3.0.CO;2-E","volume":"46","year":"1999","journal-title":"Drug Development Research"},{"issue":"14","key":"255","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1002\/1521-3773(20000717)39:14<2396::AID-ANIE2396>3.0.CO;2-U","volume":"39","year":"2000","journal-title":"Angewandte Chemie International Edition"},{"key":"256","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2013.838216"},{"issue":"2","key":"257","first-page":"178","volume":"75","year":"2013","journal-title":"Indian Journal of Pharmaceutical Sciences"},{"key":"258","doi-asserted-by":"publisher","DOI":"10.3109\/10837450.2013.813544"},{"key":"259","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2013.12.004"},{"key":"260","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.01.005"},{"issue":"5","key":"261","doi-asserted-by":"crossref","first-page":"664","DOI":"10.2174\/1568026614666140118213316","volume":"14","year":"2014","journal-title":"Current Topics in Medicinal Chemistry"},{"key":"262","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201300649"},{"key":"263","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2013.12.023"},{"key":"264","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2013.12.045"},{"issue":"5","key":"265","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3109\/1061186X.2013.878942","volume":"22","year":"2014","journal-title":"Journal of Drug Targeting"},{"issue":"24","key":"266","first-page":"3347","volume":"17","year":"2013","journal-title":"European Review Medicinal Pharmacological Sciences"},{"issue":"4","key":"267","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2174\/1567201810666140109113830","volume":"11","year":"2014","journal-title":"Current Drug Delivery"},{"issue":"3","key":"268","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2174\/1567201811666140115113127","volume":"11","year":"2014","journal-title":"Current Drug Delivery"},{"key":"269","first-page":"3","volume":"12, supplement","year":"2013","journal-title":"Iranian Journal of Pharmaceutical Research"},{"key":"270","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/25\/5\/055101"},{"key":"271","doi-asserted-by":"publisher","DOI":"10.3109\/1061186X.2013.875029"},{"key":"272","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.11.014"},{"key":"273","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201300436"},{"key":"274","doi-asserted-by":"publisher","DOI":"10.1039\/c3ob41721b"},{"key":"275","doi-asserted-by":"publisher","DOI":"10.1021\/bm4014414"},{"key":"276","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(01)00222-8"},{"key":"277","year":"2005"},{"issue":"3","key":"278","doi-asserted-by":"crossref","first-page":"C161","DOI":"10.1152\/ajpcell.1982.243.3.C161","volume":"243","year":"1982","journal-title":"American Journal of Physiology"},{"key":"279","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.01.019"},{"key":"280","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2013.843610"},{"key":"281","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-010-0309-1"},{"key":"282","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.10.033"},{"key":"283","doi-asserted-by":"publisher","DOI":"10.1002\/jps.23823"},{"key":"284","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-018093"},{"key":"285","doi-asserted-by":"publisher","DOI":"10.1021\/mp400363z"},{"key":"286","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107587"},{"issue":"14","key":"287","first-page":"2026","volume":"13","year":"2013","journal-title":"Journal of Medicinal Chemistry"},{"issue":"1","key":"288","first-page":"129","volume":"48","year":"1983","journal-title":"Immunology"},{"key":"289","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.5.2510"},{"issue":"3","key":"290","first-page":"497","volume":"74","year":"1991","journal-title":"Immunology"},{"key":"291","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002933"},{"key":"292","doi-asserted-by":"publisher","DOI":"10.1021\/bc2002133"},{"key":"293","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2014.880756"},{"key":"294","doi-asserted-by":"publisher","DOI":"10.1002\/jps.22054"},{"key":"295","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.12.001"},{"key":"296","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32549"},{"key":"297","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S24447"},{"issue":"5","key":"299","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2174\/1568026614666140118203128","volume":"14","year":"2014","journal-title":"Current Topics in Medicinal Chemistry"},{"key":"300","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.12.035"},{"key":"301","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200301694"},{"key":"302","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2003.12.032"},{"key":"303","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-9140(01)00494-5"},{"key":"304","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(03)00087-5"},{"key":"305","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(01)00246-0"},{"key":"306","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2004.08.009"},{"key":"307","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200250653"},{"key":"308","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5186.115544"},{"key":"309","doi-asserted-by":"publisher","DOI":"10.1517\/17425240903436479"},{"key":"310","doi-asserted-by":"publisher","DOI":"10.1016\/S0939-6411(99)00039-9"},{"key":"311","doi-asserted-by":"publisher","DOI":"10.1021\/nn305193d"},{"key":"312","doi-asserted-by":"publisher","DOI":"10.1021\/nn400347j"},{"key":"313","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1307152110"},{"key":"315","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2666"},{"key":"316","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevTherDrugCarrierSyst.2013006955"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/869269.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/869269.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/869269.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T22:33:59Z","timestamp":1717108439000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2014\/869269\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":311,"alternative-id":["869269","869269"],"URL":"https:\/\/doi.org\/10.1155\/2014\/869269","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}