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Given the importance of renal transplantation and the limitation of available donors, detailed analysis of factors that affect transplant survival is important. Episodes of acute allograft rejection are a negative prognostic factor for long-term graft survival. Invasive core needle biopsies are still the \u201cgoldstandard\u201d in rejection diagnostics. Nevertheless, they are cumbersome to the patient and carry the risk of significant graft injury. Notably, they cannot be performed on patients taking anticoagulant drugs. Therefore, a noninvasive tool assessing the whole organ for specific and fast detection of acute allograft rejection is desirable. We herein review SPECT- and PET-based approaches for noninvasive molecular imaging-based diagnostics of acute transplant rejection.<\/jats:p>","DOI":"10.1155\/2014\/874785","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T21:05:41Z","timestamp":1396386341000},"page":"1-7","source":"Crossref","is-referenced-by-count":10,"title":["SPECT- and PET-Based Approaches for Noninvasive Diagnosis of Acute Renal Allograft Rejection"],"prefix":"10.1155","volume":"2014","author":[{"given":"Helga","family":"Pawelski","sequence":"first","affiliation":[{"name":"Department of Medicine D, Experimental Nephrology, University of M\u00fcnster, Albert-Schweizer Campus 1, 48149 M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uta","family":"Schn\u00f6ckel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of M\u00fcnster, Albert-Schweizer Campus 1, 48149 M\u00fcnster, 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