{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:50:04Z","timestamp":1757703004282,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["HHSN261200800001E","5R21A1068111-02"],"award-info":[{"award-number":["HHSN261200800001E","5R21A1068111-02"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN261200800001E","5R21A1068111-02"],"award-info":[{"award-number":["HHSN261200800001E","5R21A1068111-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. A delayed time to pregnancy was recently reported for women who had a loop electrosurgical excision procedure (LEEP) to remove cervical intraepithelial neoplasia (CIN) grade 2 or 3. The objective of the current study was to determine if treatment of CIN with LEEP is associated with decreased levels of anti-M\u00fcllerian hormone (AMH), a marker of ovarian reserve.<jats:italic>Methods<\/jats:italic>. AMH levels were measured in 18 women treated with LEEP and 18 age-matched controls, who had colposcopy only and did not require LEEP. Cases and controls had their blood drawn at study entry time zero and again 6 months later.<jats:italic>Results<\/jats:italic>. The mean AMH level decreased significantly from baseline to follow-up; however, no significant differences were observed when stratifying by LEEP status, suggesting that both groups experienced a similar decrease in AMH levels during the follow-up period. Although women treated with LEEP had lower overall AMH levels than controls at both baseline and follow-up, these differences were not statistically significant.<jats:italic>Conclusion<\/jats:italic>. Overall, the delayed time to pregnancy observed in women treated with LEEP is likely not due to a LEEP-associated decrease in ovarian reserve as measured by AMH; thus, other mechanism are responsible for the delayed time to pregnancy associated with LEEP.<\/jats:p>","DOI":"10.1155\/2014\/875438","type":"journal-article","created":{"date-parts":[[2014,2,23]],"date-time":"2014-02-23T16:06:32Z","timestamp":1393171592000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["Does Loop Electrosurgical Excision Procedure of the Uterine Cervix Affect Anti-M\u00fcllerian Hormone Levels?"],"prefix":"10.1155","volume":"2014","author":[{"given":"Martha M.","family":"Sklavos","sequence":"first","affiliation":[{"name":"Human Papillomavirus Immunology Laboratory, Leidos Biomedical Research, Incorporated, Frederick National Laboratory for Cancer Research, Building 469, Room 111, 1050 Boyles Street, Frederick, MD 21702, 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