{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:28:57Z","timestamp":1789874937955,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy Tirgu Mures, Romania","award":["19\/11.12.2013"],"award-info":[{"award-number":["19\/11.12.2013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Oxidative damage at the DNA level may be promoted by high levels of reactive oxygen species (ROS), leading to genomic instability and increased neoplastic risk. Superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT) enzymes are implicated in the prevention of DNA damage by ROS. The aim of the study was to investigate the relationships between<jats:italic>CAT<\/jats:italic>C262T,<jats:italic>GPX1<\/jats:italic>Pro198Leu,<jats:italic>MnSOD<\/jats:italic>Ala16Val,<jats:italic>GSTM1, GSTT1<\/jats:italic>, and<jats:italic>GSTP1<\/jats:italic>Ile105Val polymorphisms and the risk of CML. No association was observed between CML and variant genotypes of<jats:italic>GPX1, MnSOD, GSTM1<\/jats:italic>, and<jats:italic>GSTT1<\/jats:italic>polymorphisms in any of the investigated cases. Our study suggests that the homozygous variant genotype of the<jats:italic>GSTP1<\/jats:italic>Ile105Val gene polymorphisms may be associated with the risk of developing CML (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>2.5<\/mml:mn><\/mml:math>; 95%\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mtext>CI<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.08<\/mml:mn><\/mml:math>\u20135.7;<jats:italic>P<\/jats:italic>value = 0.02), while the heterozygous genotype of the<jats:italic>CAT<\/jats:italic>C262T polymorphism seems to have a protective effect against CML (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.59<\/mml:mn><\/mml:math>, 95%\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mtext>CI<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.39<\/mml:mn><\/mml:math>\u20130.89,<jats:italic>P<\/jats:italic>value = 0.01). In most cases, no association was found between laboratory parameters and prognostic factors and the variant genotype of investigated gene polymorphisms. We concluded that<jats:italic>CAT, GPX, MnSOD, GSTM1<\/jats:italic>, and<jats:italic>GSTT1<\/jats:italic>gene polymorphisms are not associated with the risk of CML. Variant genotype of the<jats:italic>GSTP1<\/jats:italic>Ile105Val gene polymorphisms may contribute to the risk of developing CML.<\/jats:p>","DOI":"10.1155\/2014\/875861","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T16:05:51Z","timestamp":1415721951000},"page":"1-6","source":"Crossref","is-referenced-by-count":33,"title":["<i>CAT, GPX1, MnSOD, GSTM1, GSTT1<\/i>, and<i>GSTP1<\/i>Genetic Polymorphisms in Chronic Myeloid Leukemia: A Case-Control Study"],"prefix":"10.1155","volume":"2014","author":[{"given":"Claudia","family":"B\u0103nescu","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, University of Medicine and Pharmacy Tirgu Mures, 38 Gh. Marinescu Street, 540139 Tirgu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian P.","family":"Trifa","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 6 Louis Pasteur Street, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Septimiu","family":"Void\u0103zan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Medicine and Pharmacy Tirgu Mures, 38 Gh. Marinescu Street, 540139 Tirgu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeriu G.","family":"Moldovan","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of Medicine and Pharmacy Tirgu Mures, 38 Gh. Marinescu Street, 540139 Tirgu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioan","family":"Macarie","sequence":"additional","affiliation":[{"name":"Hematology Clinic 1, University of Medicine and Pharmacy Tirgu Mures, 50 Gh. Marinescu Street, 540136 Tirgu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erzsebeth","family":"Benedek Lazar","sequence":"additional","affiliation":[{"name":"Hematology Clinic 2, University of Medicine and Pharmacy Tirgu Mures, 38 Gh. Marinescu Street, 540139 Tirgu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"Dima","sequence":"additional","affiliation":[{"name":"\u201cIon Chiricuta\u201d Cancer Institute, 34-36 Republicii Street, 400015 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8056-1339","authenticated-orcid":true,"given":"Carmen","family":"Duicu","sequence":"additional","affiliation":[{"name":"Pediatric Clinic, University of Medicine and Pharmacy Tirgu Mures, 50 Gh. Marinescu Street, 540136 Tirgu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minodora","family":"Dobreanu","sequence":"additional","affiliation":[{"name":"Laboratory Medicine, University of Medicine and Pharmacy Tirgu Mures, 50 Gh. 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