{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T08:54:30Z","timestamp":1693385670279},"reference-count":19,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Lipids"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Treatment of hyperlipidemia is helpful in both primary and secondary prevention of coronary heart disease and stroke.<jats:italic>Aim<\/jats:italic>. To compare lipid-lowering efficacy of rosuvastatin with atorvastatin.<jats:italic>Methodology<\/jats:italic>. This open-label randomized controlled trial was carried out at 1 Mountain Medical Battalion from September 2012 to August 2013 on patients with type 2 diabetes, hypertension, myocardial infarction, or stroke, meriting treatment with a statin. Those with secondary causes of dyslipidemia were excluded. Blood samples for estimation of serum total cholesterol, triglycerides, HDL-C, and LDL-C were collected after a 12-hour fast. Patients were randomly allocated to receive either atorvastatin 10\u2009mg HS or rosuvastatin 5\u2009mg HS daily. Lipid levels were rechecked after six weeks.<jats:italic>Results<\/jats:italic>. Atorvastatin was used in 63 patients and rosuvastatin in 66. There was a greater absolute and percent reduction in serum LDL-C levels with rosuvastatin as compared to atorvastatin (0.96 versus 0.54\u2009mg\/dL;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.011<\/mml:mn><\/mml:math>and 24.34 versus 13.66%;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.045<\/mml:mn><\/mml:math>), whereas reduction in all other fractions was equal. Myalgias were seen in 5 (7.94%) patients treated with atorvastatin and 8 (12.12%) patients treated with rosuvastatin (<jats:italic>P<\/jats:italic>: 0.432).<jats:italic>Conclusion<\/jats:italic>. Rosuvastatin produces a greater reduction in serum LDL-C levels and should therefore be preferred over atorvastatin.<\/jats:p>","DOI":"10.1155\/2014\/875907","type":"journal-article","created":{"date-parts":[[2014,3,30]],"date-time":"2014-03-30T21:06:07Z","timestamp":1396213567000},"page":"1-5","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of Low-Dose Rosuvastatin with Atorvastatin in Lipid-Lowering Efficacy and Safety in a High-Risk Pakistani Cohort: An Open-Label Randomized Trial"],"prefix":"10.1155","volume":"2014","author":[{"given":"Abdul Rehman","family":"Arshad","sequence":"first","affiliation":[{"name":"Department of Medicine, 1 Mountain Medical Battalion, Bagh, Azad Kashmir 12500, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182009701"},{"issue":"5","key":"2","first-page":"551","volume":"84","year":"2011","journal-title":"American Family Physician"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1185\/030079903125002225"},{"issue":"4","key":"4","first-page":"190","volume":"21","year":"2005","journal-title":"Acta Cardiologica Sinica"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.7.725"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200847070-00003"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2296-4-1"},{"issue":"6","key":"8","doi-asserted-by":"crossref","first-page":"314","DOI":"10.5551\/jat.E567","volume":"15","year":"2008","journal-title":"Journal of Atherosclerosis and Thrombosis"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.08.051"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.002"},{"issue":"19","key":"11","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","volume":"285","year":"2001","journal-title":"Journal of the American Medical Association"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.046"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00530-7"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X112462"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.08.014"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-4-7"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3400\/avd.AVDoa090019"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/146579"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P002816"}],"container-title":["Journal of Lipids"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jl\/2014\/875907.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jl\/2014\/875907.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jl\/2014\/875907.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T10:38:24Z","timestamp":1498127904000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jl\/2014\/875907\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":19,"alternative-id":["875907","875907"],"URL":"https:\/\/doi.org\/10.1155\/2014\/875907","relation":{},"ISSN":["2090-3030","2090-3049"],"issn-type":[{"value":"2090-3030","type":"print"},{"value":"2090-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}