{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:29:05Z","timestamp":1740169745721,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Remote ischemic preconditioning (RIP) and pharmacological preconditioning are the effective methods that can be used to prevent ischemia reperfusion (IR) injury. The aim of this study was to evaluate the effects of RIP and N-Acetylcysteine (NAC) with RIP in the rat hepatic IR injury model.<jats:italic>Materials and Methods<\/jats:italic>. 28 rats were divided into 4 groups. Group I (sham): only laparotomy was performed. Group II (IR): following 30 minutes of hepatic pedicle occlusion, 4 hours of reperfusion was performed. Group III (RIP + IR): following 3 cycles of RIP, hepatic IR was performed. Group IV (RIP + NAC + IR): following RIP and intraperitoneal administration of NAC (150\u2009mg\/kg), hepatic IR was performed. All the rats were sacrificed after blood samples were taken for the measurements of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels and liver was processed for conventional histopathology.<jats:italic>Results<\/jats:italic>. The hepatic histopathological injury scores of RIP + IR and RIP + NAC + IR groups were significantly lower than IR group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.006<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.003<\/mml:mn><\/mml:math>, resp.). There were no significant differences in AST and ALT values between the IR, RIP + IR, and RIP + NAC + IR groups.<jats:italic>Conclusions<\/jats:italic>. In the present study, it was demonstrated histopathologically that RIP and RIP + NAC decreased hepatic IR injury significantly.<\/jats:p>","DOI":"10.1155\/2014\/892704","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T16:24:12Z","timestamp":1389198252000},"page":"1-6","source":"Crossref","is-referenced-by-count":4,"title":["The Effects of Remote Ischemic Preconditioning and N-Acetylcysteine with Remote Ischemic Preconditioning in Rat Hepatic Ischemia Reperfusion Injury Model"],"prefix":"10.1155","volume":"2014","author":[{"given":"Ali Ihsan","family":"Uysal","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Dokuz Eylul University Medical School, Inciralti, 35340 Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1188-0667","authenticated-orcid":true,"given":"Elvan","family":"Ocmen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Dokuz Eylul University Medical School, Inciralti, 35340 Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0195-7149","authenticated-orcid":true,"given":"Mert","family":"Akan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Dokuz Eylul University Medical School, Inciralti, 35340 Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevda","family":"Ozkardesler","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Dokuz Eylul University Medical School, Inciralti, 35340 Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bekir Ugur","family":"Ergur","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, University Medical School, 35340 Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ensari","family":"Guneli","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Science, University Medical School, 35340 Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuncay","family":"Kume","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University Medical School, 35340 Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2949-4265","authenticated-orcid":true,"given":"U\u011fur","family":"Koca","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Dokuz Eylul University Medical School, Inciralti, 35340 Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belgin","family":"Unal Togrul","sequence":"additional","affiliation":[{"name":"Department of Public Health, University Medical School, 35340 Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"6","key":"1","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1097\/00000542-200106000-00030","volume":"94","year":"2001","journal-title":"Anesthesiology"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.70.1070"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2006.00938.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060782"},{"issue":"6","key":"5","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1097\/01.sla.0000098620.27623.7d","volume":"238","year":"2003","journal-title":"Annals of Surgery"},{"key":"6","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<255::AID-PATH526>3.0.CO;2-6","volume":"190","year":"2000","journal-title":"The Journal of Pathology"},{"issue":"6","key":"7","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1002\/hep.510300622","volume":"30","year":"1999","journal-title":"Hepatology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.20529"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2011.10.006"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.4.1183"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00559-2"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7176"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.128.469"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20359"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1017\/S026502150600086X"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2005.07.028"},{"issue":"1","key":"17","first-page":"75","volume":"16","year":"2003","journal-title":"Journal of Nephrology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/micr.10041"},{"issue":"2","key":"19","first-page":"381","volume":"29","year":"2009","journal-title":"Turkiye Klinikleri Journal of Medical Sciences"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.11.002"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-8014-y"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200008000-00001"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5331"},{"issue":"3","key":"24","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1161\/01.CIR.87.3.893","volume":"87","year":"1993","journal-title":"Circulation"},{"issue":"9","key":"25","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1097\/00007890-200211150-00009","volume":"74","year":"2002","journal-title":"Transplantation"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1054\/bjps.2002.3809"},{"issue":"6","key":"27","first-page":"H2476","volume":"277","year":"1999","journal-title":"American Journal of Physiology: Heart and Circulatory Physiology"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000203555.14546.63"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22272"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1556\/OH.2008.28495"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1159\/000135707"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2012.01481.x"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181bfda8c"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/892704.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/892704.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/892704.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T01:34:42Z","timestamp":1498095282000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2014\/892704\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":33,"alternative-id":["892704","892704"],"URL":"https:\/\/doi.org\/10.1155\/2014\/892704","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2014]]}}}