{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T09:51:30Z","timestamp":1776419490893,"version":"3.51.2"},"reference-count":65,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100011665","name":"Deanship of Scientific Research","doi-asserted-by":"crossref","award":["RGP-VPP-142"],"award-info":[{"award-number":["RGP-VPP-142"]}],"id":[{"id":"10.13039\/501100011665","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. The purpose of the study is to evaluate the hepatoprotective effect of rutin in carbon tetrachloride- (CCl<jats:sub>4<\/jats:sub>-) induced liver injuries in rat model.<jats:italic>Methods<\/jats:italic>. Forty male Wistar albino rats were divided into four groups. Group I was the control group and received dimethyl sulphoxide (DMSO) and olive oil. Group II received rutin. Groups III was treated with CCl<jats:sub>4<\/jats:sub>. Group IV was administered rutin after 48 h of CCl<jats:sub>4<\/jats:sub>treatment. Liver enzymes level, lipid profile, lipid peroxidation, and hydrogen peroxide were measured. The genes expression levels were monitored by real time RT-PCR and western blot techniques.<jats:italic>Results<\/jats:italic>. CCl<jats:sub>4<\/jats:sub>group showed significant increase in alanine aminotransferase (ALT), aspartate aminotransferase (AST), thiobarbituric acid reactive substances (TBAR), hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>), and lipid profile and a significant decrease in glutathione peroxidase (GPx), glutathione S transferase (GST), catalase (CAT), paraoxonase-1 (PON-1), paraoxonase-3 (PON-3), peroxisome proliferator activated receptor delta (PPAR-<jats:italic>\u03b4<\/jats:italic>), and ATP-binding cassette transporter 1 (ABAC1) genes expression levels. Interestingly, rutin supplementation completely reversed the biochemical and gene expression levels induced by CCl<jats:sub>4<\/jats:sub>to control values.<jats:italic>Conclusion<\/jats:italic>. CCl<jats:sub>4<\/jats:sub>administration causes aberration of genes expression levels in oxidative stress pathway resulting in DNA damage and hepatotoxicity. Rutin causes hepatoprotective effect through enhancing the antioxidant genes.<\/jats:p>","DOI":"10.1155\/2014\/893212","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T21:04:54Z","timestamp":1416258294000},"page":"1-12","source":"Crossref","is-referenced-by-count":48,"title":["Association between Paraoxonases Gene Expression and Oxidative Stress in Hepatotoxicity Induced by CCl<sub>4<\/sub>"],"prefix":"10.1155","volume":"2014","author":[{"given":"Mohamed M.","family":"Hafez","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Othman A.","family":"Al-Shabanah","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. 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