{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:06:05Z","timestamp":1788242765314,"version":"build-2803163510"},"reference-count":31,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Science & Technology Project Foundation of Hubei Province","award":["2011CHB026"],"award-info":[{"award-number":["2011CHB026"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To investigate the protective effects of lipoxin A4 (LXA4) in rat testis injury following testicular torsion\/detorsion.<jats:italic>Methods<\/jats:italic>. A rat testicular torsion model has been established as described. Rats were randomly divided into 6 groups: sham group, torsion group, torsion\/detorsion (T\/D) group, and T\/D plus LXA4-pretreated groups (3 subgroups). Rats in LXA4-pretreated groups received LXA4 injection (0.1, 1.0, and 10\u2009<jats:italic>\u03bc<\/jats:italic>g\/kg body weight in LXA4-pretreated subgroups 1\u20133, resp.) at a single dose 1\u2009h before detorsion. Biochemical analysis, apoptosis assessment, and morphologic evaluation were carried out after orchiectomies.<jats:italic>Results<\/jats:italic>. GPx and SOD levels significantly increased and MDA levels significantly reduced in LXA4-pretreated groups compared to T\/D group. LXA4 also reverted IL-2 and TNF-<jats:italic>\u03b1<\/jats:italic>to basal levels and improved the expression of IL-4 and IL-10 in LXA4-pretreated groups. Moreover, the expression of NF-<jats:italic>\u03ba<\/jats:italic>B was downregulated in LXA4-pretreated groups. LXA4 treatment also showed an improved testicular morphology and decreased apoptosis in testes.<jats:italic>Conclusion<\/jats:italic>. Lipoxin A4 protects rats against testes injury after torsion\/detorsion via modulation of cytokines, oxidative stress, and NF-<jats:italic>\u03ba<\/jats:italic>B activity.<\/jats:p>","DOI":"10.1155\/2014\/898056","type":"journal-article","created":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T21:23:09Z","timestamp":1399584189000},"page":"1-9","source":"Crossref","is-referenced-by-count":15,"title":["Protective Effects of Lipoxin A4 in Testis Injury following Testicular Torsion and Detorsion in Rats"],"prefix":"10.1155","volume":"2014","author":[{"given":"Xian-Long","family":"Zhou","sequence":"first","affiliation":[{"name":"Emergency Center, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuchang, Wuhan, Hubei 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Sheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Emergency Center, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuchang, Wuhan, Hubei 430071, 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