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Twenty-three MDD patients, twenty-five BD patients, and twenty-four normal controls were enrolled and their event-related magnetoencephalographic responses were recorded during implicit emotional tasks. Our results demonstrated abnormal gamma activity within 100\u2009ms in the emotion-related regions (amygdala, orbitofrontal (OFC) cortex, anterior insula (AI), and superior temporal pole) in the MDD patients, suggesting that these patients may have dysfunctions or negativity biases in perceptual binding of emotional features at very early stage. Decreased left superior medial frontal cortex (smFC) responses to happy faces in the MDD patients were correlated with their serious level of depression symptoms, indicating that decreased smFC activity perhaps underlies irregular positive emotion processing in depressed patients. In the BD patients, we showed abnormal activation in visual regions (inferior\/middle occipital and middle temporal cortices) which responded to emotional faces within 100\u2009ms, supporting that the BD patients may hyperactively respond to emotional features in perceptual binding. The discriminant function of gamma activation in the left smFC, right medial OFC, right AI\/inferior OFC, and the right precentral cortex accurately classified 89.6% of patients as unipolar\/bipolar disorders.<\/jats:p>","DOI":"10.1155\/2014\/906104","type":"journal-article","created":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T21:03:38Z","timestamp":1394744618000},"page":"1-9","source":"Crossref","is-referenced-by-count":26,"title":["Abnormal Early Gamma Responses to Emotional Faces Differentiate Unipolar from Bipolar Disorder Patients"],"prefix":"10.1155","volume":"2014","author":[{"given":"T. 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