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HGF is a multifunctional mediator originally identified in hepatocytes and has recently been reported to possess various neuroprotective properties. This study was designed to investigate the protective effect of hUC-MSCs infected by an adenovirus carrying the<jats:italic>HGF<\/jats:italic>gene on the PD cell model induced by MPP+ on human bone marrow neuroblastoma cells. Our results provide evidence that the cultural supernatant from hUC-MSCs expressing HGF could promote regeneration of damaged PD cells at higher efficacy than the supernatant from hUC-MSCs alone. And intracellular free Ca<jats:sup>2+<\/jats:sup>obviously decreased after treatment with cultural supernatant from hUC-MSCs expressing HGF, while the expression of CaBP-D28k, an intracellular calcium binding protein, increased. Therefore our study clearly demonstrated that cultural supernatant of MSC overexpressing<jats:italic>HGF<\/jats:italic>was capable of eliciting regeneration of damaged PD model cells. This effect was probably achieved through the regulation of intracellular Ca<jats:sup>2+<\/jats:sup>levels by modulating of CaBP-D28k expression.<\/jats:p>","DOI":"10.1155\/2014\/909657","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T00:08:14Z","timestamp":1409789294000},"page":"1-7","source":"Crossref","is-referenced-by-count":23,"title":["Human Umbilical Cord Mesenchymal Stem Cells Infected with Adenovirus Expressing<i>HGF<\/i>Promote Regeneration of Damaged Neuron Cells in a Parkinson\u2019s Disease Model"],"prefix":"10.1155","volume":"2014","author":[{"given":"Xin-Shan","family":"Liu","sequence":"first","affiliation":[{"name":"Weifang Medical University, 7166 Baotong Road, Weifang 261053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Feng","family":"Li","sequence":"additional","affiliation":[{"name":"The Neurology Department, The 148th Hospital, 20 Zhanbei Road, Zibo 255300, 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