{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T01:09:00Z","timestamp":1655946540309},"reference-count":25,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"Shanghai Hospital Cooperation Foundation","doi-asserted-by":"crossref","award":["SHDC12010119","2011CB504506"],"award-info":[{"award-number":["SHDC12010119","2011CB504506"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Reactivation of latent herpes simplex type 1 (HSV-1) and nerve inflammation have been shown to be involved in vertigo-related vestibular pathogenesis. Treatments of such diseases have been less than perfect. Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to suppress reactivation of HSV-1 in trigeminal ganglions. However, whether this drug can affect reactivation of HSV-1 in vestibular ganglions is unclear. Due to the difficulties of constructing<jats:italic>in vivo<\/jats:italic>animal models, in this study, we developed a vestibular ganglion culture system, in which vestibular neurons were latently or lytically infected with HSV-1. Indomethacin and celecoxib were selected to measure their effects on HSV-1. Trichostatin A was used to reactivate HSV-1 in latently infected neurons. Cycloxygenase-2, which is the target of NSAIDs, was induced by HSV-1 in the lytically infected cultures, with an increase of 14-fold. Although it appeared that indomethacin and celecoxib showed limited but concentration-dependent inhibition effects on viral production under our condition, indomethacin decreased reactivation rate of HSV-1 by about 20%. Though more<jats:italic>in vitro<\/jats:italic>or<jats:italic>in vivo<\/jats:italic>studies are needed to confirm the effects of the drugs, our study may provide a potential way to investigate the mechanism of HSV-related vestibular pathogenesis as well as new treatments of vertigo-related diseases.<\/jats:p>","DOI":"10.1155\/2014\/912640","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T21:05:24Z","timestamp":1391634324000},"page":"1-9","source":"Crossref","is-referenced-by-count":3,"title":["The Role of Cyclooxygenase in Multiplication and Reactivation of HSV-1 in Vestibular Ganglion Neurons"],"prefix":"10.1155","volume":"2014","author":[{"given":"Yuehong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Otology and Skull Base Surgery, Eye, Ear, Nose, & Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai 200031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shufeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otology and Skull Base Surgery, Eye, Ear, Nose, & Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai 200031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengmin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otology and Skull Base Surgery, Eye, Ear, Nose, & Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai 200031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1159\/000189783"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1159\/000111042"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1053\/ajot.2001.24822"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200309000-00002"},{"issue":"1","key":"5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1001\/archotol.1997.01900010061008","volume":"123","year":"1997","journal-title":"Archives of Otolaryngology\u2014Head & Neck Surgery"},{"issue":"5","key":"6","first-page":"561","volume":"71","year":"1996","journal-title":"Hokkaido Igaku Zasshi"},{"issue":"503","key":"7","first-page":"85","year":"1993","journal-title":"Acta Oto-Laryngologica. 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