{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:26:36Z","timestamp":1787505996819,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO208\/TP4"],"award-info":[{"award-number":["KFO208\/TP4"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Faculty of the University of Bonn","award":["KFO208\/TP4"],"award-info":[{"award-number":["KFO208\/TP4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>\n                    Adipokines, such as nicotinamide phosphoribosyltransferase (NAMPT), are molecules, which are produced in adipose tissue. Recent studies suggest that NAMPT might also be produced in the tooth-supporting tissues, that is, periodontium, which also includes the gingiva. The aim of this study was to examine if and under what conditions NAMPT is produced in gingival fibroblasts and biopsies from healthy and inflamed gingiva. Gingival fibroblasts produced constitutively NAMPT, and this synthesis was significantly increased by interleukin-1\n                    <jats:italic>\u03b2<\/jats:italic>\n                    and the oral bacteria\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    and\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    . Inhibition of the MEK1\/2 and NF\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B pathways abrogated the stimulatory effects of\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    on NAMPT. Furthermore, the expression and protein levels of NAMPT were significantly enhanced in gingival biopsies from patients with periodontitis, a chronic inflammatory infectious disease of the periodontium, as compared to gingiva from periodontally healthy individuals. In summary, the present study provides original evidence that gingival fibroblasts produce NAMPT and that this synthesis is increased under inflammatory and infectious conditions. Local synthesis of NAMPT in the inflamed gingiva may contribute to the enhanced gingival and serum levels of NAMPT, as observed in periodontitis patients. Moreover, local production of NAMPT by gingival fibroblasts may represent a possible mechanism whereby periodontitis may impact on systemic diseases.\n                  <\/jats:p>","DOI":"10.1155\/2014\/912821","type":"journal-article","created":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T16:02:19Z","timestamp":1393344139000},"page":"1-10","source":"Crossref","is-referenced-by-count":40,"title":["Regulation of NAMPT in Human Gingival Fibroblasts and Biopsies"],"prefix":"10.1155","volume":"2014","author":[{"given":"Anna","family":"Damanaki","sequence":"first","affiliation":[{"name":"Clinical Research Unit 208, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Welschnonnenstrasse 17, 53111 Bonn, Germany"},{"name":"Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111 Bonn, Germany"},{"name":"Department of Oral Surgery, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Nokhbehsaim","sequence":"additional","affiliation":[{"name":"Clinical Research Unit 208, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Welschnonnenstrasse 17, 53111 Bonn, Germany"},{"name":"Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4619-2461","authenticated-orcid":true,"given":"Sigrun","family":"Eick","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Laboratory of Oral Microbiology, University of Bern, 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"G\u00f6tz","sequence":"additional","affiliation":[{"name":"Clinical Research Unit 208, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Welschnonnenstrasse 17, 53111 Bonn, Germany"},{"name":"Department of Orthodontics, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Winter","sequence":"additional","affiliation":[{"name":"Clinical Research Unit 208, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Welschnonnenstrasse 17, 53111 Bonn, Germany"},{"name":"Department of Periodontology, Operative and Preventive Dentistry, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Wahl","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"J\u00e4ger","sequence":"additional","affiliation":[{"name":"Clinical Research Unit 208, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Welschnonnenstrasse 17, 53111 Bonn, Germany"},{"name":"Department of Orthodontics, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Jepsen","sequence":"additional","affiliation":[{"name":"Clinical Research Unit 208, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Welschnonnenstrasse 17, 53111 Bonn, Germany"},{"name":"Department of Periodontology, Operative and Preventive Dentistry, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8808-8769","authenticated-orcid":true,"given":"James","family":"Deschner","sequence":"additional","affiliation":[{"name":"Clinical Research Unit 208, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Welschnonnenstrasse 17, 53111 Bonn, Germany"},{"name":"Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"issue":"4","key":"2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00784-003-0236-1","volume":"7","year":"2003","journal-title":"Clinical Oral Investigations"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2005.03.001"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2013.8"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.100638"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00360.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100321"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2010.00808.x"},{"issue":"2","key":"9","first-page":"107","volume":"7","year":"2009","journal-title":"Oral Health & Preventive Dentistry"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3552"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2007.00221.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/biof.185"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0674"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1201"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.4274\/Jcrpe.547"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.4172\/1948-593X.1000038"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1042\/CS20070196"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.2174\/138161210791208947"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.100690"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110272"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3233\/DMA-2012-0897"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-013-0935-1"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/437123"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/202530"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01696.x"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01357.x"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-010-0505-8"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2012.01467.x"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2011.41.3.149"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-011-0043-0"},{"issue":"6","key":"31","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1600-0765.1989.tb00883.x","volume":"24","year":"1989","journal-title":"Journal of Periodontal Research"},{"issue":"2","key":"32","first-page":"99","volume":"93","year":"1994","journal-title":"Journal of the Formosan Medical Association"},{"issue":"7","key":"33","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1600-0765.1996.tb01414.x","volume":"31","year":"1996","journal-title":"Journal of Periodontal Research"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2005.00113.x"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.2174\/1389203033486983"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.2174\/1389203033487036"},{"issue":"2","key":"37","first-page":"25","volume":"13","year":"2011","journal-title":"Current Issues in Molecular Biology"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-011-0654-4"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090051"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00449-08"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.6.3140-3146.2000"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2008.00481.x"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2009.01222.x"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.90292"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.72.9.1254"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2014\/912821.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2014\/912821.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2014\/912821.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T04:34:46Z","timestamp":1498106086000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/mi\/2014\/912821\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":45,"alternative-id":["912821","912821"],"URL":"https:\/\/doi.org\/10.1155\/2014\/912821","relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}