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However, the main questions on the physiopathology of Chagas disease remain unanswered: \u201cWhy does the host immune system fail to provide sterile immunity?\u201d and \u201cWhy do only a proportion of infected individuals develop chronic pathology?\u201d In this review, we describe the mechanisms proposed to explain the inability of the immune system to eradicate the parasite and the elements that allow the development of chronic heart disease. Moreover, we discuss the possibility that the inability of infected cardiomyocytes to sense intracellular\n                    <jats:italic>T. cruzi<\/jats:italic>\n                    contributes to parasite persistence in the heart and the development of chronic pathology.\n                  <\/jats:p>","DOI":"10.1155\/2014\/912965","type":"journal-article","created":{"date-parts":[[2014,6,29]],"date-time":"2014-06-29T18:36:53Z","timestamp":1404067013000},"page":"1-9","source":"Crossref","is-referenced-by-count":26,"title":["Chagas Disease: Still Many Unsolved Issues"],"prefix":"10.1155","volume":"2014","author":[{"given":"Jos\u00e9 M.","family":"\u00c1lvarez","sequence":"first","affiliation":[{"name":"Department of Immunology, Biomedical Sciences Institute, University of S\u00e3o Paulo, 05508-000 S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raissa","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Immunology, Biomedical Sciences Institute, University of S\u00e3o Paulo, 05508-000 S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique","family":"Borges da Silva","sequence":"additional","affiliation":[{"name":"Department of Immunology, Biomedical Sciences Institute, University of S\u00e3o Paulo, 05508-000 S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udio R. 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