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Increased platelet activation, enhanced red blood cell aggregation, and an imbalance between procoagulant and anticoagulant factors are thought to underlie the excessive thrombotic risk in patients with nephrotic syndrome. The current scientific literature suggests that patients with low serum albumin levels and membranous nephropathy may benefit from primary prophylactic anticoagulation. A thorough approach which includes accounting for all additional thrombotic risk factors is, therefore, essential. Patient counseling regarding the pros and cons of anticoagulation is of paramount importance. Future prospective randomized studies should address the question regarding the utility of primary thromboprophylaxis in patients with nephrotic syndrome.<\/jats:p>","DOI":"10.1155\/2014\/916760","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T21:13:30Z","timestamp":1397682810000},"page":"1-9","source":"Crossref","is-referenced-by-count":37,"title":["Primary Nephrotic Syndrome in Adults as a Risk Factor for Pulmonary Embolism: An Up-to-Date Review of the Literature"],"prefix":"10.1155","volume":"2014","author":[{"given":"Aibek E.","family":"Mirrakhimov","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Saint Joseph Hospital, 2900 N. Lake Shore, Chicago, IL 60657, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa M.","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Saint Joseph Hospital, 2900 N. 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