{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T23:11:25Z","timestamp":1784848285612,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","award":["POSDRU\/159\/1.5\/S\/136893"],"award-info":[{"award-number":["POSDRU\/159\/1.5\/S\/136893"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To investigate oxidative stress (OS) and histological changes that occur in the periodontium of subjects with type 2 diabetes mellitus without signs of periodontal disease and to establish if oxidative stress is a possible link between diabetes mellitus and periodontal changes.<jats:italic>Materials and Methods<\/jats:italic>. Tissue samples from ten adult patients with type 2 diabetes mellitus (T2D) and eight healthy adults were harvested. The specimens were examined by microscope using standard hematoxylin-eosin stain, at various magnifications, and investigated for tissue levels of malondialdehyde (MDA) and glutathione (GSH).<jats:italic>Results<\/jats:italic>. Our results showed that periodontal tissues in patients with T2D present significant inflammation, affecting both epithelial and connective tissues. Mean MDA tissue levels were 3.578 \u00b1 0.60\u2009SD in diabetics versus 0.406 \u00b1 0.27\u2009SD in controls (<jats:italic>P<\/jats:italic>&lt; 0.0001), while mean GSH tissue levels were 2.48 \u00b1 1.02\u2009SD in diabetics versus 9.7875 \u00b1 2.42\u2009SD in controls (<jats:italic>P<\/jats:italic>&lt; 0.0001).<jats:italic>Conclusion<\/jats:italic>. Diabetic subjects had higher MDA levels in their periodontal tissues, suggesting an increased lipid peroxidation in T2D, and decreased GSH tissue levels, suggesting an alteration of the local antioxidant defense mechanism. These results are in concordance with the histological changes that we found in periodontal tissues of diabetic subjects, confirming the hypothesis of OS implication, as a correlation between periodontal disease incidence and T2D.<\/jats:p>","DOI":"10.1155\/2014\/917631","type":"journal-article","created":{"date-parts":[[2014,11,30]],"date-time":"2014-11-30T21:01:28Z","timestamp":1417381288000},"page":"1-4","source":"Crossref","is-referenced-by-count":51,"title":["Oxidative Stress: A Link between Diabetes Mellitus and Periodontal Disease"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4417-6879","authenticated-orcid":true,"given":"Adriana","family":"Monea","sequence":"first","affiliation":[{"name":"Department of Odontology and Periodontology, Faculty of Dental Medicine, University of Medicine and Pharmacy T\u00e2rgu Mure\u0219, 38 Gheorghe Marinescu Street, 540114 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Mezei","sequence":"additional","affiliation":[{"name":"Department of Morphopathology, Faculty of Medicine, University of Medicine and Pharmacy T\u00e2rgu Mure\u0219, 38 Gheorghe Marinescu Street, 540114 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin","family":"Popsor","sequence":"additional","affiliation":[{"name":"Department of Prosthetics and Oral Rehabilitation, Faculty of Dental Medicine, University of Medicine and Pharmacy T\u00e2rgu Mure\u0219, 38 Gheorghe Marinescu Street, 540114 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Monea","sequence":"additional","affiliation":[{"name":"Department of Odontology and Periodontology, Faculty of Dental Medicine, University of Medicine and Pharmacy T\u00e2rgu Mure\u0219, 38 Gheorghe Marinescu Street, 540114 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.4.547-558.2000"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.07.001"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031163"},{"issue":"7","key":"4","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1093\/clinchem\/37.7.1273","volume":"37","year":"1991","journal-title":"Clinical Chemistry"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86135-I"},{"issue":"3","key":"7","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jn\/134.3.489","volume":"134","year":"2004","journal-title":"Journal of Nutrition"},{"issue":"33","key":"8","doi-asserted-by":"crossref","first-page":"17205","DOI":"10.1016\/S0021-9258(19)77815-6","volume":"263","year":"1988","journal-title":"The Journal of Biological Chemistry"},{"key":"9","first-page":"1","volume-title":"Oxidan\u0163ii \u015fi antioxidan\u0163ii","year":"2006"},{"issue":"3","key":"10","first-page":"491","volume":"53","year":"2012","journal-title":"Romanian Journal of Morphology and Embryology"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2008.02.002"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.2.195"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198805193182007"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.14.6434"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1996.tb01417.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2337\/diab.37.12.1595"},{"key":"17","year":"2008"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/45794"}],"container-title":["International Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2014\/917631.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2014\/917631.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2014\/917631.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T14:45:52Z","timestamp":1650725152000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ije\/2014\/917631\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":18,"alternative-id":["917631","917631"],"URL":"https:\/\/doi.org\/10.1155\/2014\/917631","relation":{},"ISSN":["1687-8337","1687-8345"],"issn-type":[{"value":"1687-8337","type":"print"},{"value":"1687-8345","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}