{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:13Z","timestamp":1771632013963,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. We compared the characteristics of patients with Cushing\u2019s disease alone with those of patients with Cushing\u2019s disease and hyperprolactinemia.<jats:italic>Methods<\/jats:italic>. Eighty-four patients were enrolled between 2002 and 2011, in a hospital in China. Clinical, endocrinological, and histopathological data, MRI scans, and surgical outcomes were reviewed throughout the follow-up period.<jats:italic>Results<\/jats:italic>. Patients with Cushing\u2019s disease and hyperprolactinemia had a younger age at diagnosis (30.28 \u00b1 14.23 versus 36.08 \u00b1 10.91 years;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.037<\/mml:mn><\/mml:math>) and a larger adenoma maximal diameter (2.44 \u00b1 1.32 versus 1.44 \u00b1 1.05 cm;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>) than patients with Cushing\u2019s disease alone. Menstrual disorders (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.027<\/mml:mn><\/mml:math>) and visual field defects (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.021<\/mml:mn><\/mml:math>) were more common and progressive obesity (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.009<\/mml:mn><\/mml:math>) and hypertension (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>) were less common in patients with Cushing\u2019s disease and hyperprolactinemia. The rate of normalization of hormonal levels was lower (41.7% versus 91.7%;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>) and the recurrence rate was higher (36.1% versus 8.3%;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>) in patients with Cushing\u2019s disease and hyperprolactinemia.<jats:italic>Conclusions<\/jats:italic>. Careful long-term follow-up is needed of patients with Cushing\u2019s disease and hyperprolactinemia.<\/jats:p>","DOI":"10.1155\/2014\/919704","type":"journal-article","created":{"date-parts":[[2014,11,23]],"date-time":"2014-11-23T16:00:56Z","timestamp":1416758456000},"page":"1-8","source":"Crossref","is-referenced-by-count":5,"title":["Retrospective Analysis of Cushing\u2019s Disease with or without Hyperprolactinemia"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1212-6220","authenticated-orcid":true,"given":"Cheng","family":"Huan","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250000, 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