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As a subtype of MCI, amnestic mild cognitive impairment (aMCI) most often leads to Alzheimer\u2019s disease. This study aims to elucidate the altered brain activation in patients with aMCI using resting-state functional magnetic resonance. We observed Frequency-dependent changes in the amplitude of low-frequency fluctuations in aMCI patients (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>20<\/mml:mn><\/mml:math>), and normal subjects (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>18<\/mml:mn><\/mml:math>). At the same time, we took gray matter volume as a covariate. We found that aMCI patients had decreased amplitude of low-frequency fluctuation signal in left superior temporal gyrus, right middle temporal gyrus, right inferior parietal lobe, and right postcentral gyrus compared to the control group. Specially, aMCI patients showed increased signal in left superior and middle frontal gyrus. Our results suggested that increased activation in frontal lobe of aMCI patients may indicate effective recruitment of compensatory brain resources. This finding and interpretation may lead to the better understanding of cognitive changes of aMCI.<\/jats:p>","DOI":"10.1155\/2014\/920902","type":"journal-article","created":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T17:05:52Z","timestamp":1397495152000},"page":"1-7","source":"Crossref","is-referenced-by-count":50,"title":["Selective Changes of Resting-State Brain Oscillations in aMCI: An fMRI Study Using ALFF"],"prefix":"10.1155","volume":"2014","author":[{"given":"Zhilian","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China"},{"name":"Beijing Key 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