{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:48:23Z","timestamp":1788522503409,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Genetics"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. We hereby describe what we believe to be the first reported case of t (14; 15) (q32; q13) associated with acute myeloid leukemia (AML).<jats:italic>Methods<\/jats:italic>. PubMed, Embase, and OVID search engines were used to review the related literature and similar published cases.<jats:italic>Case<\/jats:italic>. A47-year-old female presented in December 2011 with AML (acute myelomonocytic leukemia) with normal cytogenetics; molecular testing revealed FLT-3 internal tandem duplication (ITD) mutation, while no mutations involving FLT3 D385\/I836, NPM1 exon 12, or KIT exons 8 and 17 were detected. She was induced with 7\u2009+\u20093 (cytarabine + idarubicin) and achieved complete remission after a second induction with high-dose cytarabine (HiDAC) followed by uneventful consolidation. She presented 19 months after diagnosis with relapsed disease. Of note, at relapse cytogenetic analysis revealed t (14; 15) (q32; q13), while FLT-3 analysis showed a codon D835 mutation (no ITD mutation was detected). She proved refractory to the initial clofarabine-based regimen, so FLAG-idarubicin then was used. She continued to have persistent disease, and she was discharged on best supportive care.<jats:italic>Conclusion<\/jats:italic>. Based on this single case of AML with t (14; 15) (q32; q13), this newly reported translocation may be associated with refractory disease.<\/jats:p>","DOI":"10.1155\/2014\/921240","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T21:06:15Z","timestamp":1415739975000},"page":"1-4","source":"Crossref","is-referenced-by-count":1,"title":["A Case of Acute Myeloid Leukemia with a Previously Unreported Translocation (14; 15) (q32; q13)"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6627-1933","authenticated-orcid":true,"given":"Mohamad","family":"Khawandanah","sequence":"first","affiliation":[{"name":"Hematology-Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA"},{"name":"University of Oklahoma Health Sciences Center, Stephenson Cancer Center, 800 NE 10th Street, Oklahoma City, OK 73102, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1550-3455","authenticated-orcid":true,"given":"Bradley","family":"Gehrs","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Holter Chakrabarty","sequence":"additional","affiliation":[{"name":"Hematology-Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Cherry","sequence":"additional","affiliation":[{"name":"Hematology-Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0492"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12131"},{"key":"3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/(SICI)1098-2264(199906)25:2<123::AID-GCC8>3.0.CO;2-4","volume":"25","year":"1999","journal-title":"Genes Chromosomes Cancer"},{"issue":"5","key":"4","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","volume":"84","year":"1994","journal-title":"Blood"},{"issue":"4","key":"5","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1200\/JCO.1998.16.4.1270","volume":"16","year":"1998","journal-title":"Journal of Clinical Oncology"},{"issue":"6","key":"6","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1182\/blood.V82.6.1820.1820","volume":"82","year":"1993","journal-title":"Blood"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.6.2185"},{"key":"8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3892\/br.2012.9","volume":"1","year":"2013","journal-title":"Biomedical Reports"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402249"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(03)00302-9"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22850"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20846"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(98)00234-9"}],"container-title":["Case Reports in Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crig\/2014\/921240.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crig\/2014\/921240.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crig\/2014\/921240.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T18:01:02Z","timestamp":1598464862000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crig\/2014\/921240\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":13,"alternative-id":["921240","921240"],"URL":"https:\/\/doi.org\/10.1155\/2014\/921240","relation":{},"ISSN":["2090-6544","2090-6552"],"issn-type":[{"value":"2090-6544","type":"print"},{"value":"2090-6552","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}