{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:27:48Z","timestamp":1793420868322,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>This study presents effects of intravenous laser blood irradiation (ILBI) in a transient immunodeficiency patient with juvenile idiopathic arthritis (JIA) treated with an interleukin-6 receptor inhibitor (Tocilizumab). Biological agents induce JIA remission, but some patients do not respond favorably to this final therapeutic line of defense. ILBI was performed in a 16-year-old male patient, with JIA and transient immunodeficiency. When ILBI was introduced, the patient was receiving disease-modifying drugs, steroids, tocilizumab, and physical therapy. Because the disease was not well controlled, ILBI was applied in addition to other ongoing therapies. The patient underwent 1 session daily, and 10 successive sessions per month, repeated every 3 months, for 7 months. Patient evaluation was performed before ILBI was started and at 3, 6, 9, and 12 months after ILBI initiation, using the ACR Pediatric response. The outcome was evaluated using Pediatric 50, 70, and 90 responses and compared to initial status, after 3, 6, 9, and 12 months. At the end of study, the titre of IgA and IgG levels returned to normal. Synergistic anti-inflammatory effect of ILBI was evident, if applied additionally in combination with tocilizumab, in a patient with a therapy-resistant severe form of JIA and related subacute transient immunodeficiency.<\/jats:p>","DOI":"10.1155\/2014\/923496","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T16:10:28Z","timestamp":1393949428000},"page":"1-6","source":"Crossref","is-referenced-by-count":10,"title":["Intravenous Laser Blood Irradiation and Tocilizumab in a Patient with Juvenile Arthritis"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1485-0543","authenticated-orcid":true,"given":"Dragos Andrei","family":"Chiran","sequence":"first","affiliation":[{"name":"Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Weber","sequence":"additional","affiliation":[{"name":"Institute for Laser Therapy and Acupuncture, Sohnreystra\u00dfe 6, 37697 Lauenf\u00f6rde, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Marinela","family":"Ailioaie","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, \u201cAlexandru Ioan Cuza\u201d University, 11 Carol I Boulevard, 700506 Iasi, Romania"},{"name":"Laser Clinic, 83 Arcu Street, 700135 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eovelina","family":"Moraru","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"Second Pediatric Clinic, Street Mary Emergency Hospital for Children, 62 Vasile Lupu St., 700309 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2306-1020","authenticated-orcid":true,"given":"Constantin","family":"Ailioaie","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"Laser Clinic, 83 Arcu Street, 700135 Iasi, Romania"},{"name":"Second Pediatric Clinic, Street Mary Emergency Hospital for Children, 62 Vasile Lupu St., 700309 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1883-3521","authenticated-orcid":true,"given":"Daniela","family":"Litscher","sequence":"additional","affiliation":[{"name":"Research Unit of Biomedical Engineering in Anesthesia and Intensive Care Medicine and TCM Research Center Graz, Medical University of Graz, Auenbruggerplatz 29, 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6287-0130","authenticated-orcid":true,"given":"Gerhard","family":"Litscher","sequence":"additional","affiliation":[{"name":"Research Unit of Biomedical Engineering in Anesthesia and Intensive Care Medicine and TCM Research Center Graz, Medical University of Graz, Auenbruggerplatz 29, 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.068064"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2013.735657"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2012.03.014"},{"issue":"1, supplement b","key":"4","first-page":"1","volume":"18","year":"2012","journal-title":"Journal of Managed Care Pharmacy"},{"key":"5","first-page":"664","volume-title":"The intravenous laser blood irradiation. 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