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Thus, we compared expressions of selected T cell, B cell, and macrophage markers in five areas of DLE, psoriasis, and normal skin. Immunostainings for CD3, CD4, CD8, CD20, CD68, CXCR3, CXCL10, and TIA-1 were performed in biopsies of 23 DLE lesional skin, 11 psoriasis lesional skin, and 5 normal skin. Three independent observers used a graded scale to rate each marker\u2019s presence in the epidermis, dermatoepidermal junction (DEJ), perivascular area, periadnexal area, and deep dermis. DLE lesional skin contained an increased abundance of CD3<jats:sup>+<\/jats:sup>, CD8<jats:sup>+<\/jats:sup>, and CD68<jats:sup>+<\/jats:sup>cells at the DEJ, and CD20<jats:sup>+<\/jats:sup>and CD68<jats:sup>+<\/jats:sup>cells in the periadnexal area versus psoriasis and normal skin. CXCR3, CXCL10, and TIA-1 were elevated in periadnexal sites of DLE lesional skin versus psoriasis lesional skin. The aggregation of T cells, B cells, macrophages, and their protein products (CXCR3, CXCL10, and TIA-1) in the DEJ and periadnexal area of DLE lesional skin may contribute to the pathology of DLE through a coordinated, sophisticated process.<\/jats:p>","DOI":"10.1155\/2014\/925805","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T21:03:07Z","timestamp":1394571787000},"page":"1-12","source":"Crossref","is-referenced-by-count":18,"title":["Site-Specific Analysis of Inflammatory Markers in Discoid Lupus Erythematosus Skin"],"prefix":"10.1155","volume":"2014","author":[{"given":"Ryan B.","family":"Thorpe","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9069, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas 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