{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:18:14Z","timestamp":1780406294441,"version":"3.54.1"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271158"],"award-info":[{"award-number":["81271158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Z131100006813027"],"award-info":[{"award-number":["Z131100006813027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Science and Technology Program Fund","award":["81271158"],"award-info":[{"award-number":["81271158"]}]},{"name":"Beijing Science and Technology Program Fund","award":["Z131100006813027"],"award-info":[{"award-number":["Z131100006813027"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Oxidative stress biomarkers have been observed in peripheral blood of chronic periodontitis patients; however, their associations with periodontitis were not consistent. This meta-analysis was performed to clarify the associations between chronic periodontitis and oxidative biomarkers in systemic circulation. Electronic searches of PubMed and Embase databases were performed until October 2014 and articles were selected to meet inclusion criteria. Data of oxidative biomarkers levels in peripheral blood of periodontitis patients and periodontal healthy controls were extracted to calculate standardized mean differences (SMDs) and 95% confidence intervals (CIs) by using random-effects model. Of 31 eligible articles, 16 articles with available data were included in meta-analysis. Our results showed that periodontitis patients had significantly lower levels of total antioxidant capacity (SMD = \u22122.02; 95% CI: \u22123.08, \u22120.96;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.000<\/mml:mn><\/mml:math>) and higher levels of malondialdehyde (SMD = 0.99; 95% CI: 0.12, 1.86;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.026<\/mml:mn><\/mml:math>) and nitric oxide (SMD = 4.98; 95% CI: 2.33, 7.63;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.000<\/mml:mn><\/mml:math>) than periodontal healthy control. Superoxide dismutase levels between two groups were not significantly different (SMD = \u22121.72; 95% CI: \u22123.50, 0.07;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.059<\/mml:mn><\/mml:math>). In conclusion, our meta-analysis showed that chronic periodontitis is significantly associated with circulating levels of three oxidative stress biomarkers, indicating a role of chronic periodontitis in systemic diseases.<\/jats:p>","DOI":"10.1155\/2014\/931083","type":"journal-article","created":{"date-parts":[[2014,11,16]],"date-time":"2014-11-16T16:05:45Z","timestamp":1416153945000},"page":"1-10","source":"Crossref","is-referenced-by-count":51,"title":["Systemic Oxidative Stress Biomarkers in Chronic Periodontitis: A Meta-Analysis"],"prefix":"10.1155","volume":"2014","author":[{"given":"Zhiqiang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Stomatology, Beijing ChaoYang Hospital Affiliated to Capital Medical University, Beijing 100020, China"},{"name":"Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Beijing ChaoYang Hospital Affiliated to Capital Medical University, Beijing 100020, China"},{"name":"Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Vascular Medicine, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songlin","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuomin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Beijing ChaoYang Hospital Affiliated to Capital Medical University, Beijing 100020, China"},{"name":"Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of 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