{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:00:59Z","timestamp":1791961259183,"version":"4.3.4"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"SERC Division, Department of Science and Technology, New Delh","award":["SR\/FT\/L-81\/2006"],"award-info":[{"award-number":["SR\/FT\/L-81\/2006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Catharanthus roseus<\/jats:italic>(L.) G. Don, a medicinal plant, has a very important place in the traditional as well as modern pharmaceutical industry. Two common varieties of this plant<jats:italic>rosea<\/jats:italic>and<jats:italic>alba<\/jats:italic>are named so because of pink and white coloured flowers, respectively. This plant comprises of about 130 terpenoid indole alkaloids and two of them, vincristine and vinblastine, are common anticancer drugs. The effect of chromium (Cr) on enzymatic and non-enzymatic antioxidant components and on secondary metabolites vincristine and vinblastine was studied under pot culture conditions of both varieties of<jats:italic>C. roseus<\/jats:italic>. Antioxidant responses of these varieties were analyzed under 0, 10, 50, and 100\u2009<jats:italic>\u03bc<\/jats:italic>M chromium (Cr) level in order to investigate the plant\u2019s protective mechanisms against Cr induced oxidative stress. The results indicated that Cr affects all the studied parameters and decreases growth performance. However, vincristine and vinblastine contents were increased under Cr stress. Results are quite encouraging, as this plant shows good antioxidant potential and increased the level of active constituents under Cr stress.<\/jats:p>","DOI":"10.1155\/2014\/934182","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T21:04:29Z","timestamp":1394485469000},"page":"1-10","source":"Crossref","is-referenced-by-count":75,"title":["Effect of Chromium on Antioxidant Potential of<i>Catharanthus roseus<\/i>Varieties and Production of Their Anticancer Alkaloids: Vincristine and Vinblastine"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8326-1801","authenticated-orcid":true,"given":"Vartika","family":"Rai","sequence":"first","affiliation":[{"name":"Department of Botany, University of Lucknow, Lucknow 226 007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod Kumar","family":"Tandon","sequence":"additional","affiliation":[{"name":"Department of Botany, University of Lucknow, 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