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Animals were treated with SPRT (0.3, 0.6, and 1.2\u2009g\/kg) and showed remarkable hepatoprotection against CCl\n                    <jats:sub>4<\/jats:sub>\n                    -induced hepatotoxicity. CCl\n                    <jats:sub>4<\/jats:sub>\n                    altered various biochemical parameters in rat liver, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), superoxide dismutase (SOD), histopathological changes, and Bax and caspase-3 expressions. SPRT significantly prevented increases in ALT and AST levels, reduced MDA level, decreased Bax and caspase-3 protein expression, enhanced SOD activity, and provided significant amelioration in the histopathological lesions. These findings suggested that SPRT has significant protective effect against acute hepatotoxicity induced by CCl\n                    <jats:sub>4<\/jats:sub>\n                    in rats.\n                  <\/jats:p>","DOI":"10.1155\/2014\/934732","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T17:25:48Z","timestamp":1402334748000},"page":"1-6","source":"Crossref","is-referenced-by-count":16,"title":["Hepatoprotective Effect of Superfine Particles of Herbal Medicine against CCl\n                    <sub>4<\/sub>\n                    -Induced Acute Liver Damage in Rats"],"prefix":"10.1155","volume":"2014","author":[{"given":"Gang","family":"Cao","sequence":"first","affiliation":[{"name":"Research Center of TCM Processing Technology, Zhejiang Chinese Medical University, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglin","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocheng","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sicong","family":"Tu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of New South Wales, Sydney, NSW 2031, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","first-page":"205","volume":"4","year":"2009","journal-title":"Asian Journal of Traditional Medicines"},{"key":"2","first-page":"208","volume":"18","year":"2009","journal-title":"Journal of Chinese Pharmaceutical Sciences"},{"issue":"7","key":"3","first-page":"1042","volume":"33","year":"2010","journal-title":"Journal of Chinese Medicinal Materials"},{"key":"4","first-page":"347","volume":"5","year":"2012","journal-title":"Anti-Tumor Pharmacy"},{"key":"5","first-page":"33","volume":"41","year":"2012","journal-title":"Journal of Medical Research"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2011.08.015"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2010.05.009"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2008.08.002"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2006.03.009"},{"key":"10","first-page":"13","volume":"51","year":"2013","journal-title":"China Modern Doctor"},{"key":"11","first-page":"134","volume":"18","year":"2011","journal-title":"Chinese Journal of Traditional Medical Science and Technology"},{"key":"12","first-page":"502","volume":"21","year":"2009","journal-title":"Natural Product Research and Development"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067306"},{"issue":"1","key":"14","first-page":"10","volume":"5","year":"2013","journal-title":"Hygeia: Journal for Drugs and Medicines"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/934732.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/934732.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/934732.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,11,6]],"date-time":"2016-11-06T16:01:50Z","timestamp":1478448110000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2014\/934732\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":14,"alternative-id":["934732","934732"],"URL":"https:\/\/doi.org\/10.1155\/2014\/934732","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}