{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:15:31Z","timestamp":1740165331315,"version":"3.37.3"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Dermatological Medicine"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Natural killer (NK) cells were proposed to play an important role in the pathogenesis of human T-cell lymphotropic virus type 1- (HTLV-1-) associated neurologic disease. Our patient was a 77-year-old Japanese man, who had been treated for infective dermatitis associated with HTLV-1 for nearly 10 years. When referred to us, he had facial eczema\/edema as well as extensive dermatitis at the neck\/upper chest and nuchal area\/upper back regions. Dermal lesions had CD3+CD4+ cells, but no NK cells. Flow cytometry of his peripheral blood showed a phenotype of CD2+ (97%), CD3+ (17%), CD4+ (12%), CD7+ (94%), CD8+ (6%), CD11c+ (70%), CD16+ (82%), CD19+ (0%), CD20+ (0%), CD56+ (67%), HLA-DR+ (68%), and NKp46+ (36%). Absolute numbers of CD56+NK cells in the peripheral blood were in a range of 986\/<jats:italic>\u03bc<\/jats:italic>L\u20131,270\/<jats:italic>\u03bc<\/jats:italic>L. The expanded NK cells in the peripheral blood are considered to be reactive, to maintain the confinement of the HTLV-1-positive CD4+ cells in the skin, and to prevent the progression of the disease.<\/jats:p>","DOI":"10.1155\/2014\/937513","type":"journal-article","created":{"date-parts":[[2014,11,9]],"date-time":"2014-11-09T21:02:50Z","timestamp":1415566970000},"page":"1-4","source":"Crossref","is-referenced-by-count":1,"title":["Expansion of Natural Killer Cells in Peripheral Blood in a Japanese Elderly with Human T-Cell Lymphotropic Virus Type 1-Related Skin Lesions"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9795-0819","authenticated-orcid":true,"given":"Shinsaku","family":"Imashuku","sequence":"first","affiliation":[{"name":"Division of Hematology, Takasago Seibu Hospital, 1-10-41 Nakasuji, Takasago 676-0812, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Kudo","sequence":"additional","affiliation":[{"name":"Division of Hematology, Takasago Seibu Hospital, 1-10-41 Nakasuji, Takasago 676-0812, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kagekatsu","family":"Kubo","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Takasago Seibu Hospital, Takasago 676-0812, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouichi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Kurume University, Kurume 830-0011, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04568.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002328"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12007"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb00223.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05606.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04008.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.4161\/viru.1.1.9868"},{"issue":"12","key":"5","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.4049\/jimmunol.149.12.4101","volume":"149","year":"1992","journal-title":"Journal of Immunology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050405"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.04882.x"}],"container-title":["Case Reports in Dermatological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cridm\/2014\/937513.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cridm\/2014\/937513.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cridm\/2014\/937513.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:32:25Z","timestamp":1689640345000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cridm\/2014\/937513\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":10,"alternative-id":["937513","937513"],"URL":"https:\/\/doi.org\/10.1155\/2014\/937513","relation":{},"ISSN":["2090-6463","2090-6471"],"issn-type":[{"type":"print","value":"2090-6463"},{"type":"electronic","value":"2090-6471"}],"subject":[],"published":{"date-parts":[[2014]]}}}